郭丽霞　胡兆鹏　邓勇

[关键词] 左半结肠癌;右半结肠癌;生存率;Meta分析

[中图分类号] R735.1          [文献标识码] A          [文章编号] 1673-9701（2021）14-0016-04

Meta analysis of the survival rate of patients with left and right colon cancer in China

GUO Lixia1   HU Zhaopeng1   DENG Yong2

1.Department of Pathology， Pingxiang People′s Hospital in Jiangxi Province， Pingxiang   337000， China; 2.Department of Infectious Diseases， Pingxiang NO.2 People′s Hospital in Jiangxi Province， Pingxiang   337000， China

[Abstract] Objective To explore the difference in 1， 3， and 5-year survival rates of patients with colon cancer in China using systematic evaluation methods， and provide evidence-based evidence for clinical prognosis evaluation and individualized treatment. Methods The CNKI， Weipu， and Wanfang Chinese databases were searched by computer. The studies of the prognosis of left and right colon cancer in China were collected. The search time was from January 2010 to June 2020. Two reviewers screened the literature and extracted the data according to the inclusion and exclusion criteria. RevMan 5.3 software was used for statistical analysis. Results A total of 9 studies were included， and 2923 investigators were included. Meta analysis showed that the 1-year survival rate of left and right colon cancer was not much different（94.4% vs. 92.1%）. But the 5-year survival rate of left colon cancer （57.2%） was significantly higher than in right colon cancer （48.3%） （RR=1.68， 95%CI： 1.44-1.97， P<0.00001）. Conclusion The 1-year survival rate of patients with left colon cancer is not significantly different from that of patients with right colon cancer， but the 3-year survival rate and 5-year survival rate of patients with left colon cancer are significantly higher than those of patients with right colon cancer.

[Key words] Left colon cancer; Right colon cancer; Survival rate; Meta analysis

結肠癌是常见的消化系统恶性肿瘤之一，不同地区其发病率和死亡率有所差异，但在各种癌症中结肠直癌的发病率非常高，在美国结直肠癌是各种癌症中死亡的第二大原因[1]。结肠癌根据其解剖位置的差异可以分为左半结肠癌和右半结肠癌，国内外有许多研究[2-4]认为，左半结肠癌和右半结肠癌是两种不同的癌症，二者在发病机制、组织与分子生物学分析及预后方面均存在一定差异性。本文就左右半结肠癌的1年生存率、3年生存率和5年生存率进行荟萃分析，从而进一步明确左右半结肠癌的生存率是否的确存在差异，为临床诊治及预后提供依据，现报道如下。

1 资料与方法

1.1 纳入及排除标准

所有纳入的研究类型均为回顾性分析。研究对象均通过手术切除行病理检测证实为结肠癌。干预措施：单个研究中的入组对象的治疗措施相同，但所有纳入的研究不局限于何种治疗方法，干预措施包括手术治疗、化疗及分子靶向治疗等。结局指标：对患者进行随访，分为1、3和5年生存率。纳入标准：①随访时间超过3年;②左右半结肠治疗措施具有可比性;③结肠癌诊断依据为病理结果。排除标准：①同一篇文献中左右半结肠癌的治疗措施不一致者;②随访不规范者。

1.2 检索策略

计算机检索维普、CNK和万方中文数据库，收集左右半结肠癌预后有关的文献，检索时限均从2010年1月至2020年6月。……