李伟超

【摘要】 目的：探讨结直肠癌患者术后应用益生菌对免疫力与炎性因子的影响。方法：选取2014年1-12月本院收治的結直肠癌患者66例，应用随机数字表法将其分为对照组和研究组，每组33例。所有患者均进行手术治疗，术后对照组进行常规治疗，研究组在对照组的基础上给予益生菌治疗。比较两组患者各项血清免疫球蛋白、炎性因子、免疫功能水平及术后并发症发生情况。结果：术后7 d，研究组各项血清免疫球蛋白水平均高于对照组（P<0.05）;术后7 d，研究组炎性因子水平均低于对照组（P<0.05）;术后7 d，研究组免疫功能水平均高于对照组（P<0.05）;术后，研究组并发症发生率低于对照组（P<0.05）。结论：在结直肠癌术后的治疗中，益生菌的使用可以促进免疫功能恢复，降低炎性因子水平，减少并发症发生，维护细胞免疫稳态，值得临床应用。

【关键词】 结直肠癌 益生菌 免疫力 炎性因子

Effect of Probiotics on Immunity and Inflammatory Factors in Patients with Colorectal Cancer after Operation/LI Weichao. //Medical Innovation of China， 2021， 18（12）： 0-060

[Abstract] Objective： To investigate the effect of probiotics on immunity and inflammatory factors in patients with colorectal cancer after operation. Method： A total of 66 patients with colorectal cancer in our hospital from January to December 2014 were selected， they were randomly divided into control group and study group， 33 cases in each group. All patients were treated with surgery， the control group was treated with conventional treatment， and the study group was treated with probiotics on the basis of the control group. The levels of serum immunoglobulin， inflammatory factors， immune function and postoperative complications between two groups were compared. Result： 7 d after operation， serum immunoglobulin levels in the study group were higher than those in the control group （P<0.05）; 7 d after operation， the levels of inflammatory factors in the study group were lower than those in the control group （P<0.05）; 7 d after operation， the level of immune function in the study group was higher than that in the control group （P<0.05）; after operation， the incidence of complications in the study group was lower than that in the control group （P<0.05）. Conclusion： In the postoperative treatment of colorectal cancer， the use of probiotics can promote the recovery of immune function， reduce the level of inflammatory factors， reduce complications， and maintain cellular immune homeostasis， which is worthy of clinical application.

[Key words] Colorectal cancer Probiotics Immunity Inflammatory factors

First-authors address： Fengcheng Peoples Hospital， Fengcheng 331100， China

doi：10.3969/j.issn.1674-4985.2021.12.013

随着人们饮食、生活方式的改变，结直肠癌发生、致死率不断升高，在临床消化系统恶性肿瘤中排第四[1]。该疾病发生初期症状不显著，随着疾病的发展，肿瘤的恶化，患者会逐渐出现排便异常、腹泻、便血等症状，癌症晚期患者则会出现严重贫血、体重明显降低，对患者的生命健康产生了非常大的影响[2]。早中期患者一般是进行手术治疗，但是术后患者的免疫力明显降低，这对于身体恢复、延长生存时间是不利的，因此，术后给予患者相应的药物治疗非常重要[3]。有学者认为，益生菌属于微生物制剂，可以改善患者的肠道内化环境，增强黏膜通透性，提高患者的免疫力[4]。但是临床关于该方面的研究比较少，此次研究探讨结直肠癌患者术后应用益生菌对免疫力与炎性因子的影响，希望可以为临床提供依据，现将研究结果报道如下。

1 资料与方法

1.1 一般资料 选取2014年1-12月本院收治的结直肠癌患者66例，应用隨机数字表法将其分为对照组和研究组，每组33例。……