王荣华

【摘要】 目的：观察右美托咪定对妇科腹腔镜围手术期患者炎性因子的影响效果，并探究其临床适用性。方法：选择2014年11月-2015年9月于笔者所在医院接受治疗的90例行妇科腹腔镜手术患者作为研究对象，根据治疗方案不同，分为研究组和对照组。对照组患者给予注射生理盐水进行麻醉，研究组患者给予注射右美托咪定进行麻醉。观察两组患者各时间点血浆炎性因子浓度；并比较两组患者术后不良反应情况。结果：两组患者T1时间点IL-6及TNF-α浓度比较，差异均无统计学意义（P>0.05）；研究组患者T2、T3、T4时间点IL-6及TNF-α浓度均显著小于对照组，两组比较，差异均有统计学意义（P<0.05）；研究组患者寒战、恶心呕吐、T4心动过速、T4躁动发生率均显著低于对照组，差异均有统计学意义（P<0.05）。结论：右美托咪定对妇科腹腔镜围手术期患者炎性因子的影响效果显著，术后不良反应少，适合临床长期推广应用。

【关键词】 右美托咪定； 腹腔镜围手术期； 炎性因子； 影响

doi：10.14033/j.cnki.cfmr.2016.36.009 文献标识码 B 文章编号 1674-6805（2016）36-0019-02

Effect Observation of Dexmedetomidine on the Inflammatory Factors of Laparoscopic Gynecologic Perioperative Patients/WANG Rong-hua.//Chinese and Foreign Medical Research，2016，14（36）：19-20

【Abstract】 Objective：To observe the effect of Dexmedetomidine on the inflammatory factors of laparoscopic gynecologic perioperative patients，and to explore its clinical applicability.Method：90 cases of gynecological patients with gynecological laparoscopic operation from November 2014 to September 2015 in our hospital were selected as the research object，according to the different treatment options，they were divided into study group and control group.The control group was treated with saline injection anesthesia，patients in the study group were given injection of Dexmedetomidine anesthesia.Plasma inflammatory cytokine concentrations of the two groups of patients at each time point were compared，and the adverse reactions after the surgery were compared between the two groups.Result：The differences in the IL-6 and TNF-α concentrations of the two groups at T1 were not statistically significant（P>0.05）.The IL-6 and TNF-α concentrations of the study group at T2，T3，T4 time point were significantly lower than those of the control group，the differences were statistically significant（P<0.05）.The incidence rates of chills，nausea and vomiting，T4 tachycardia，T4 restlessness in the study group were significantly lower than those in the control group，the differences were statistically significant（P<0.05）.Conclusion：Dexmedetomidine has significant effect on the inflammatory factors of laparoscopic gynecologic perioperative patients，the postoperative adverse reactions are less，it is suitable for long-term clinical application.

【Key words】 Dexmedetomidine； Laparoscopic surgery； Inflammatory factors； Influence

First-authors address：The Ninety-fifth Hospital of Chinese Peoples Liberation Army，Putian 351100，China

腹腔镜手术是临床上的常见术式，腹腔镜手术具有术后恢复快、微创、并发症少、出血量少等优点，因此在临床妇科手术中的应用较为广泛。但腹腔镜术中的麻醉、手术创伤、气腹等均可导致机体发生强烈的应激反应，从而导致患者术后出现各种器官功能失调，严重者会影响患者的生活质量和生命安全[1]。因此采用何种方案可以显著地治疗妇科腹腔镜围手术期患者炎性因子显得尤为重要。临床上常采用注射生理盐水进行治疗妇科腹腔镜围术期患者的炎性因子，效果欠佳[2]。有研究表明，右美托咪定可以顯著地改善妇科腹腔镜围手术期患者炎性因子，效果良好[3]。笔者所在医院就右美托咪定对妇科腹腔镜围手术期患者炎性因子的影响效果进行观察，现报道如下。 ……