黎永祥　　腾政杰　　李梦瑶　　寇雨顺　　何亚丽　　申进增　　伊琳

[摘要] 高血压肾损伤是临床常见病，也是高血压的严重并发症，随着高血压患者的增加及日趋年轻化，由此导致的肾脏损伤也在与日俱增，高血压肾损伤在全世界范围内发病率呈上升趋势，严重威胁着人类的健康和生存质量。原发性高血压长期控制不佳，特别是由于恶性高血压的控制失调，引起肾脏血流动力学改变，进而导致肾小球硬化、肾小管萎缩、肾间质纤维化，并逐渐出现肾功能不全的临床表现，即为高血压肾损伤。研究发现，非编码RNA在高血压及高血压肾损伤中存在特异性表达并发挥重要作用，为高血压肾损害的机制研究及靶向治疗提供新思路，本文就高血压肾损伤中的非编码RNA的特异性表达、作用机制、作用靶点的研究进展作出如下综述。

[关键词] 非编码RNA;高血压;高血压肾损伤;研究进展

[中图分类号] R544.1          [文献标识码] A          [文章编号] 1673-9701（2021）10-0187-06

Research progress of non-coding RNA in hypertension and hypertensive renal injury

LI Yongxiang1   TENG Zhengjie2   LI Mengyao1   KOU Yushun1   HE Yali1   SHEN Jinzeng1   YI Lin1

1.School of Integrated Chinese and Western Medicine， Gansu University of Chinese Medicine， Lanzhou   730000， China; 2.Department of Cardiovascular Medicine， Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou   730000， China

[Abstract] Hypertensive kidney injury is a common clinical disease and a serious complication of hypertension. With the increase in the number of hypertensive patients and the decrease in the age of onset， the kidney injury caused by this is also increasing daily. The incidence of hypertensive kidney injury is increasing worldwide， which seriously threatens human health and quality of life. The long-term poor control of essential hypertension， especially the control disorder due to the malignant hypertension， causes renal hemodynamic changes， which in turn leads to clinical manifestations such as glomerular sclerosis， renal tubular atrophy， renal interstitial fibrosis， and gradual occurrence of renal insufficiency， namely hypertensive kidney injury. Studies have found that non-coding RNA has a specific expression and plays an important role in hypertension and hypertensive kidney injury， which provides new ideas for the mechanism research and targeted therapy of hypertensive renal damage. This article summarizes the research progress of specific expression of non-coding RNA， mechanism of action， and targets of action in hypertensive kidney injury.

[Key words] Non-coding RNA; Hypertension; Hypertensive kidney injury; Research progress

高血壓作为一种“心血管综合征”，是最常见的心血管疾病之一，危害不仅表现为血压升高，更重要的是在高动力状态下对心、脑、肾、血管等靶器官的损害，高血压已经是导致终末期肾病（End stage renal disease，ESRD）的主要原因之一，也是导致人类死亡的常见疾病，严重威胁着人类的健康和生存质量。血压异常波动与心脑血管事件发生密切相关，并且可以导致心、脑、肾等多种靶器官的损害[1]，随着我国社会经济的快速发展以及居民生活方式的改变，我国高血压的患病率在快速增长，虽然我国高血压患者的知晓率、治疗率、控制率较于以前有所改善，但是和其他发达国家相比仍然处于较低的水平。……