范海博

[摘要] 目的 探討血清三叶因子1（TFF1）、糖类抗原153（CA153）水平检测对乳腺癌的诊断价值。 方法 回顾性分析2019年1—12月我院接受诊疗的35例乳腺癌患者临床资料，将其设为乳腺癌组，另选取同期于我院接受诊疗的32例良性乳腺疾病患者为良性乳腺疾病组、30例健康体检者为健康对照组，所有入选者均接受血清TFF1、CA153水平检测，比较三组血清血清TFF1、CA153水平差异，并分析上述两项指标检测在乳腺癌中的诊断价值。结果 乳腺癌组TFF1、CA153水平高于良性乳腺疾病组及健康对照组，差异有统计学意义（P<0.05）;绘制ROC曲线显示，TFF1、CA153单项及联合检测用于乳腺癌诊断的AUC分别为0.820、0.771、0.853，灵敏度分别为0.844、0.781、0.875，特异度分别为0.771、0.714、0.829，均具有一定诊断价值。 结论 血清TFF1、CA153水平检测作为简单、经济、可重复的检测手段，在乳腺癌诊断中具有一定价值，联合诊断可提高诊断准确度，可应用于乳腺癌筛查及早期诊断，进而为临床治疗方案制定提供有效依据。

[关键词] 乳腺癌;三叶因子1;糖类抗原153;诊断价值

[中图分类号] R737.9          [文献标识码] B          [文章编号] 1673-9701（2021）10-0065-03

Analysis of the value of serum TFF1 and CA153 in the diagnosis of breast cancer

FAN  Haibo

Department of Laboratory Medicine， Jiamusi Maternal and Child Health Hospital in Heilongjiang Province， Jiamusi   154002， China

[Abstract] Objective To explore the diagnostic value of serum trefoil factor 1（TFF1） and carbohydrate antigen 153 （CA153） levels in breast cancer. Methods The clinical data of 35 breast cancer patients who were diagnosed and treated in our hospital from January to December 2019 were retrospectively analyzed. The patients were set as the breast cancer group. 32 cases of benign breast diseases who were diagnosed and treated in our hospital during the same period were selected as the benign breast disease group. 30 healthy subjects were set as the healthy control group. All the selected subjects were tested for serum TFF1 and CA153 levels. The differences in serum TFF1 and CA153 levels between the three groups were compared， and the diagnostic value of the above two indicators in breast cancer was analyzed. Results The levels of TFF1 and CA153 in the breast cancer group were higher than those in the benign breast disease group and the healthy control group， and the difference was statistically significant（P<0.05）. ROC curve showed that the AUC of TFF1 and CA153 and combined detection for breast cancer diagnosis were 0.820， 0.771， and 0.853 respectively; the sensitivity was 0.844， 0.781， 0.875; the specificity was 0.771， 0.714， 0.829， all of which had certain diagnostic value. Conclusion Serum TFF1 and CA153 level detection， as a simple， economical and reproducible detection method， has certain value in the diagnosis of breast cancer. Combined diagnosis can improve the accuracy of diagnosis， and can be used in breast cancer screening and early diagnosis， and then can provide an effective basis for the formulation of clinical treatment plans.

[Key words] Breast cancer; Trefoil factor 1; Carbohydrate antigen 153; Diagnostic value

乳腺癌是临床女性中常见的恶性肿瘤，具有较高发病率，且呈年轻化趋势，严重威胁女性健康[1]。乳腺癌早期诊断并积极采取干预措施对改善患者预后意义重大。血清糖类抗原153（Serum carbohydrate antigen 153，CA153）是临床诊断乳腺癌常用标志物，可用于乳腺癌患者的早期诊断，并可对预后做出有效评估[2-3]。三叶因子1（trefoil factor 1，TFF1）为小分子多肽，主要由胃肠道黏液细胞分泌。近年来有研究表明，TFF1在胃癌、肝癌、胰腺癌、乳腺癌等多种肿瘤组织中呈高表达，在肿瘤细胞增殖、凋亡中起到重要调控作用，且参与肿瘤血管形成及肿瘤细胞转移[4-5]。TFF1是否能够作为诊断、评估乳腺癌新的生物标志物，已成为临床研究热点。基于此，本研究通过对血清TFF1、CA153水平检测，旨在观察其单独及联合检测在乳腺癌患者中的诊断价值，现报道如下。

1 资料与方法

1.1 一般资料

回顾性分析2019年1—12月于我院接受诊疗的35例乳腺癌患者临床资料，将其设为乳腺癌组，另选取同期32例良性乳腺疾病患者为良性乳腺疾病组、30例健康体检者为健康对照组，所有入选者均为女性。……