王新亭 陈欣菊 王莉姣 张传雷 陈晓琦 曾振军

摘要：目的 观察康艾注射液治疗癌因性疲乏的临床疗效。方法 将40例癌性疲乏患者随机分为观察组和对照组，每组各20例，对照组给予对症治疗，观察组在对照组基础上给予康艾注射液，10 d为1疗程。采用FSI疲乏量表、中医症状评分表、生活质量量表比较患者疲乏情况并测定2组患者治疗前后血清中白细胞介素-1β（IL-1β）水平。结果 治疗后观察组FSI评分、IL-113水平较治疗前下降（P<0.05），且对照组的下降程度显著优于对照组（P<0.05）;观察组的生存质量改善率及中医证候积分改善率与对照组比较，差异具有统计学意义（P<0.05）。结论 康艾注射液有改善癌因性疲乏的作用，能提高中晚期肿瘤患者的生存质量。

关键词：肿瘤;癌因性疲乏;康艾注射液;临床观察

中图分类号：R255.2 文献标志码：B 文章编号：1007-2349（2021）03-0028-04

【Abstract】Objective： To observe the clinical effect of Kangai Injection in the treatment of cancer-related fatigue. Methods： 40 patients with cancerous fatigue were randomly divided into an observation group and a control group， 20 cases per group. The control group was given symptomatic treatment and the observation group was given Kangai Injection on the basis treatment of the control group， 10 days as a course of treatment. The FSI fatigue scale， the TCM symptom score scale， and the quality of life scale were used to compare the fatigue of the patients and to determine the serum interleukin-1β （IL-1β） levels of the two groups before and after treatment. Results： After treatment， the FSI score and IL-113 levels of the observation group were lower than those of the pre-treatment （P<0.05）， and the degree of decline in the observation group was significantly better than that of the control group （P<0.05）. In comparison of the quality of life improvement rate and TCM syndrome of the improvement rate of the TCM symptom score of the observation group and the control group， the difference was statistically significant （P<0.05）. Conclusion： Kangai Injection can improve cancer-related fatigue and improve the quality of life of patients with middle and advanced tumors.

【Key words】Tumor;Cancer-related fatigue;Kangai Injection;Clinical observation

姑息治療是中晚期癌症患者治疗重要方面。目前针对终末期癌症患者的癌性疼痛、心理健康等研究较多，而癌因性疲乏（cancer related fatigue，CRF）也是此类患者常见症状，CRF是一种痛苦的、持续的、主观的乏力感或疲惫感，与活动不成比例，与癌症或癌症的治疗有关，并常伴有功能障碍。有报道显示，34%～76%的癌症患者存在CRF[1-2]，目前临床上多以营养支持、改善睡眠、纠正电解质紊乱、激素等治疗为主，而针对癌因性疲乏仍是姑息治疗的难点之一。

祖国医学认为癌因性疲乏属中医“虚劳”范畴，脏腑的气血阴阳受损难以恢复所致益气扶正是治疗此类疾病的主线[3]。许多证据表明，炎症细胞因子在癌因性疲乏中发挥了重要作，CRF患者存在血清中IL-1β水平升高，慢性炎症持续刺激促进机体出现疲劳[4]。康艾注射液是益气扶正代表药物之一，具有改善患者免疫功能、抗肿瘤细胞增殖、抗炎等功能[5]。本研究以中晚期肿瘤患者为研究对象，探讨康艾注射液对癌因性疲乏的治疗效果并对血清IL-1β因子的影响，现报道如下。……