李影明 卢君

【摘要】 目的：探究乙酰半胱氨酸霧化对支气管肺炎患儿痰液黏稠度及痰液炎症因子的影响。方法：选取2018年10月-2020年6月的82例支气管肺炎患儿为研究对象，将其随机分为常规支气管肺炎治疗组（对照组）和常规治疗联合乙酰半胱氨酸雾化组（观察组），每组41例。比较两组临床总有效率、治疗前后痰液黏稠度及痰液炎症因子（白细胞介素及其他炎症因子）水平。结果：观察组治疗3、5 d后临床总有效率均显著高于对照组，差异均有统计学意义（P<0.05）。两组治疗前痰液黏稠度及痰液炎症因子比较，差异均无统计学意义（P>0.05）;观察组治疗3、5 d后痰液黏稠度均显著优于对照组，痰液炎症因子均显著低于对照组，差异均有统计学意义（P<0.05）。结论：乙酰半胱氨酸雾化在支气管肺炎患儿中的应用效果较好，且可显著改善痰液黏稠度与痰液炎症因子水平，因此在支气管肺炎患儿中的应用价值相对较高。

【关键词】 乙酰半胱氨酸 雾化 支气管肺炎 痰液黏稠度 炎症因子

Study on Influence of Acetylcysteine by Atomization for Sputum Viscosity and Sputum Inflammatory Factors of Children with Bronchopneumonia/LI Yingming， LU Jun. //Medical Innovation of China， 2021， 18（34）： 0-089

[Abstract] Objective： To investigate the influence of Acetylcysteine by atomization for sputum viscosity and sputum inflammatory factors of children with bronchopneumonia. Method： A total of 82 children with bronchopneumonia from October 2018 to June 2020 were chosen as the study objects， and they were randomly divided into routine treatment for bronchopneumonia group （the control group） and routine treatment combined with Acetylcysteine by atomization group （the observation group）， 41 cases in each group. Then the total effective rates， sputum viscosity and sputum inflammatory factors （interleukins and other inflammatory factors） before and after treatment of two groups were compared. Result： The total effective rates of the observation group at 3， 5 d after treatment were significantly higher than those of the control group， there were statistically significant differences （P<0.05）. The sputum viscosity and sputum inflammatory factors of two groups before treatment were compared， there were no statistically significant differences （P>0.05）; the sputum viscosity of the observation group at 3， 5 d after treatment were significantly better than those of the control group， the sputum inflammatory factors were significantly lower than those of the control group， there were statistically significant differences （P<0.05）. Conclusion： The application effect of Acetylcysteine by atomization in the treatment of children with bronchopneumonia is better， and it can significantly improve the sputum viscosity and sputum inflammatory factors of children， so its application value in the children with bronchopneumonia is relatively higher.

[Key words] Acetylcysteine Atomization Bronchopneumonia Sputum viscosity Inflammatory factors

First-author’s address： Jiamusi Maternal and Child Health Hospital， Jiamusi 154000， China

doi：10.3969/j.issn.1674-4985.2021.34.020

支气管肺炎是儿童常见呼吸道疾病，本类患儿可表现为咳嗽、发热、气促等症状体征，对患儿的生存质量及生长发育均极为不利。临床中与支气管肺炎相关的治疗研究多见，其中乙酰半胱氨酸应用于支气管肺炎患儿的研究虽可见，但是采用雾化治疗方式的效果研究仍有待进一步深入[1-2]。同时，痰液黏稠度及痰液炎症因子作为在本类患儿中研究较多的方面，乙酰半胱氨酸雾化治疗对其的影响研究不足[3-4]。……