宋怡 王立媛

【摘要】 目的：探討无痛分娩对妊娠期高血压疾病产妇血液黏度、血管舒缩物质及疼痛物质表达的影响。方法：选取2018年6月-2020年10月本溪市中心医院的92例妊娠期高血压疾病产妇为研究对象，将其随机分为观察组和对照组，每组46例。观察组采用无痛分娩，对照组未镇痛。观察与比较两组干预前后的血液黏度（全血黏度及全血还原黏度）、血管舒缩物质[尾加压素Ⅱ（UⅡ）、内皮素-1（ET-1）及血管紧张素Ⅱ（AngⅡ）]及疼痛物质[P物质（SP）及前列腺素E2（PGE2）]。结果：干预前，两组血液黏度、血管舒缩物质及疼痛物质比较，差异均无统计学意义（P>0.05），活跃期、宫口开全时及胎儿娩出后观察组血液黏度、血管舒缩物质及疼痛物质均显著低于对照组，差异均有统计学意义（P<0.05）。结论：无痛分娩可显著影响妊娠期高血压疾病产妇血液黏度、血管舒缩物质及疼痛物质的表达，在妊娠期高血压疾病产妇中的应用价值较高。

【关键词】 无痛分娩 妊娠期高血压疾病 血液黏度 血管舒缩物质

Study on the Influence of Painless Delivery on Expression of Blood Viscosity， Vasomotor Substance and Pain Substances in Delivery Women with Hypertensive Disorder Complicating Pregnancy/SONG Yi， WANG Liyuan. //Medical Innovation of China， 2021， 18（32）： -151

[Abstract] Objective： To investigate the influence of painless delivery on expression of blood viscosity， vasomotor substance and pain substances in delivery women with hypertensive disorder complicating pregnancy. Method： A total of 92 delivery women with hypertensive disorder complicating pregnancy in Benxi Central Hospital from June 2018 to October 2020 were chosen as the research objects， and they were randomly divided into the observation group and the control group， with 46 cases in each group. The observation group was given painless delivery， while the control group was not given analgesia. The blood viscosity （whole blood viscosity and whole blood reduced viscosity）， vasomotor substance [urotensin Ⅱ （UⅡ）， edothelin-1 （ET-1） and angiotension Ⅱ （AngⅡ）] and pain substance [substance P （SP） and prostaglandin E2 （PGE2）] of the two groups before and after intervention were observed and compared. Result： There were no significant differences in blood viscosity， vasomotor substances and pain substances between the two groups before intervention （P>0.05）， the blood viscosity， vasomotor substance and pain substance of the observation group were all significantly lower than those of the control group during the active period， the whole time of uterine opening and after fetal delivery， there were statistically significant differences （P<0.05）. Conclusion： Thepainless delivery can significantly improve the expression of blood viscosity，vasomotor substance and pain substances of delivery women with hypertensive disorder complicating pregnancy is better， and its application value in pregnant women with hypertension is higher.

[Key words] Painless delivery Hypertensive disorder complicating pregnancy Blood viscosity Vasomotor substance

First-author’s address： Benxi Central Hospital， Benxi 117000， China

doi：10.3969/j.issn.1674-4985.2021.32.037

妊娠期高血压疾病产妇围生期的注意事项相对更多，有效控制围生期血压是降低子痫及缺氧等的必要前提。妊娠期高血压疾病产妇的血液黏度相对较高，而围生期此类情况进一步加重，因此对妊娠期高血压疾病产妇进行围生期血液黏度的监测与调控需求较高[1-2]。血管舒缩物质与血压密切相关[3-5]。本研究探讨无痛分娩对妊娠期高血压疾病产妇血液黏度、血管舒缩物质及疼痛物质表达的影响，现报道如下。

1 资料与方法