彭枝枝 吴薇

【摘要】 目的：觀察与分析老年非酒精性脂肪肝合并慢阻肺患者血脂及其代谢相关指标的变化情况。方法：选取2018年10月-2020年11月60例老年非酒精性脂肪肝合并慢阻肺患者为A组，同时期的60例老年非酒精性脂肪肝患者为B组，60例体检健康者为C组。比较三组的血脂（TG、TC、LDL-C）及其代谢相关指标（血清脂联素、瘦素）;比较A组及B组中不同脂肪肝严重程度者的血脂及其代谢相关指标;采用Spearman秩相关分析血脂及其代谢相关指标与老年非酒精性脂肪肝合并慢阻肺的关系。结果：三组TG、TC、LDL-C比较，差异均有统计学意义（P<0.05）。A组TG、TC、LDL-C均高于B组和C组，且B组均高于C组，差异均有统计学意义（P<0.05）。A、B组中不同脂肪肝严重程度者的TG、TC、LDL-C比较，差异均有统计学意义（P<0.05）。A组的瘦素均高于B、C组，脂联素均低于B、C组，B组瘦素高于C组，脂联素低于C组，差异均有统计学意义（P<0.05）。A、B组中不同脂肪肝严重程度者的脂联素、瘦素比较，差异均有统计学意义（P<0.05）。Spearman秩相关显示，血脂及其代谢相关指标均与老年非酒精性脂肪肝合并慢阻肺有密切的关系（P<0.05）。结论：老年非酒精性脂肪肝合并慢阻肺患者血脂及其代谢相关指标显著异常，应重视对上述方面的监测与调控。

【关键词】 非酒精性脂肪肝 慢阻肺 血脂

Observation on the Change of Blood Lipid and Its Metabolism Related Indexes of Elderly Patients with Nonalcoholic Fatty Liver Disease Complicated with Chronic Obstructive Pulmonary Disease/PENG Zhizhi， WU Wei. //Medical Innovation of China， 2021， 18（32）： -179

[Abstract] Objective： To observe and analyze the change situation of blood lipid and its metabolism related indexes of elderly patients with nonalcoholic fatty liver disease complicated with chronic obstructive pulmonary disease. Method： A total of 60 elderly patients with non-alcoholic fatty liver disease complicated with chronic obstructive pulmonary disease in our hospital from October 2018 to November 2020 were selected as group A， 60 elderly patients with non-alcoholic fatty liver disease during the same period were selected as group B， and 60 healthy subjects were selected as group C. The blood lipid （TG， TC， LDL-C） and its metabolism related indexes （serum adiponectin， leptin） were compared among three groups; the blood lipid and metabolism related indexes of patients with different severity of fatty liver in group A and group B were compared; the Spearman correlation analysis and metabolism of blood lipid and its relevant indicators of senile COPD merger of nonalcoholic fatty liver disease. Result： There were statistically significant differences in TG， TC and LDL-C among three groups （P<0.05）. TG， TC and LDL-C in the group A were higher than those in the group B and group C， and those in the group B were higher than those in the group C， the differences were statistically significant （P<0.05）. There were statistically significant differences in blood lipid indexes of patients with different severity of fatty liver in the group A and group B （P<0.05）. The serum leptin in the group A was higher than those in the group B and C， and the serum adiponectin in the group B was lower than those in the group B and group C， the differences were statistically significant （P<0.05）. There were statistically significant differences in metabolism related indexes of patients with different fatty liver severity grades in group A and group B （P<0.05）. Spearman rank correlation showed that there were close relationships between serum blood lipid indexes， metabolism related indexes and elderly patients with nonalcoholic fatty liver disease complicated with chronic obstructive pulmonary disease （P<0.05）. Conclusion： The blood lipid and its metabolism related indexes of elderly patients with nonalcoholic fatty liver disease combined with chronic obstructive pulmonary disease are significantly abnormal，and those items should be paid to more monitoring and control.

[Key words] Nonalcoholic fatty liver disease Chronic obstructive pulmonary disease Blood lipid

First-author’s address： Jinzhou Medical University， Jinzhou 121000， China

doi：10.3969/j.issn.1674-4985.2021.32.044

受多方面因素影响，脂肪肝在我国的发病率持续提升，而其中较多为非酒精性脂肪肝，且患者中较多为老年患者，此类患者的代谢减慢，且易于并发多类慢性基础疾病[1-2]。因此老年非酒精性脂肪肝合并慢阻肺患者并不乏见，但是针对本类患者的细致全面研究极为匮乏。……