周海琴

【摘要】 目的：觀察与研究慢阻肺并发院内肺部感染患者气道阻力及炎性应激的变化情况。方法：选取2019年9月-2020年8月襄阳市中医医院90例慢阻肺并发院内肺部感染患者为A组，同时期的90例慢阻肺无肺部感染患者为B组，90名健康同龄者为C组。比较三组的气道阻力指标及炎性应激指标，并比较A组及B组中相同GOLD分级者的检测结果，采用Pearson相关性分析气道阻力指标及炎性应激指标与慢阻肺院内肺部感染的关系。结果：A组的气道阻力指标及炎性应激指标均显著高于B组及C组，

B组则均显著高于C组，A组及B组中相同GOLD分级者的检测结果比较，差异均有统计学意义（P<0.05）。Pearson相关性分析显示，气道阻力指标及炎性应激指标与慢阻肺院内肺部感染有密切的关系（P<0.05）。结论：慢阻肺并发院内肺部感染患者的气道阻力及炎性应激指标呈现显著异常的状态，应加强对本类患者上述方面的监测与干预。

【关键词】 慢阻肺 院内肺部感染 气道阻力 炎性应激

Observation on the Change of Airway Resistance and Inflammatory Stress of Patients with Chronic Obstructive Pulmonary Disease Complicated with Nosocomial Pulmonary Infection/ZHOU Haiqin. //Medical Innovation of China， 2021， 18（32）： 0-055

[Abstract] Objective： To observe and study the change situation of airway resistance and inflammatory stress of patients with chronic obstructive pulmonary disease complicated with nosocomial pulmonary infection. Method： A total 90 patients with chronic obstructive pulmonary disease complicated with nosocomial pulmonary infection in Xiangyang Hospital of Traditional Chinese Medicine from September 2019 to August 2020 were chosen as group A， 90 patients with chronic obstructive pulmonary disease and without pulmonary infection at the same time were chosen as group B， 90 healthy persons of the same age were chosen as group C. Then the airway resistance indexes and inflammatory stress indexes of three groups were compared， and the detection results of group A and group B with the same GOLD stages were compared too， then the correlation between the airway resistance indexes， inflammatory stress indexes and chronic obstructive pulmonary disease complicated with nosocomial pulmonary infection were analyzed with Pearson correlation analysis. Result： The airway resistance indexes and inflammatory stress indexes of group A were significantly higher than those of group B and group C， the results of group B were significantly higher than those of group C， the detection results of group A and group B with the same GOLD stages were compared， there were statistically significant differences （P<0.05）. Pearson correlation analysis showed the airway resistance indexes and inflammatory stress indexes were closed with chronic obstructive pulmonary disease complicated with nosocomial pulmonary infection （P<0.05）. Conclusion： The airway resistance and inflammatory stress indexes of patients with chronic obstructive pulmonary disease complicated with nosocomial pulmonary infection show significantly abnormal state， and those items of these patients should be paid to more monitoring and intervention.

[Key words] Chronic obstructive pulmonary disease Nosocomial pulmonary infection Airway resistance

Inflammatory stress

First-author’s address： Xiangyang Hospital of Traditional Chinese Medicine， Xiangyang 441000， China

doi：10.3969/j.issn.1674-4985.2021.32.013

慢阻肺是呼吸系統常见慢性病之一，其对患者的危害不仅仅局限于呼吸系统，对患者机体整体及生存质量的危害极为显著。而与慢阻肺相关的研究显示，肺部感染在本类患者中发生率较高，且其中不乏院内肺部感染的患者，而这进一步影响到患者的健康及生存状态，因此对慢阻肺并发院内肺部感染的诊治与防控需求较高[1-2]。气道阻力作为在呼吸系统疾病患者中研究较多的方面，其在慢阻肺患者中的变化研究可见[3-5]，但是对于合并院内肺部感染患者中的变化研究不足。……