李彬彬 谭美华 殷章亮

【摘要】 目的：分析康柏西普聯合全视网膜激光光凝治疗缺血型视网膜中央静脉阻塞伴黄斑水肿患者的效果，为今后治疗提供有利参考依据。方法：选取本院2016年10月-2020年12月收治的缺血性视网膜中央静脉阻塞伴黄斑水肿患者86例（86眼），根据治疗方式分成两组，对照组（n=41，41眼）行康柏西普0.05 mL（0.5 mg）玻璃体腔注射;观察组（n=45，45眼）在对照组基础上，第3次注射后第7天行全视网膜激光光凝治疗。治疗后1、2、3、6个月检测患者最佳矫正视力与黄斑中心凹视网膜厚度。结果：观察组不同时间点的最佳矫正视力和CMT比较，差异均有统计学意义（P<0.05）;对照组不同时间点的最佳矫正视力和CMT比较，差异均有统计学意义（P<0.05）;治疗后6个月，观察组的CMT低于对照组，差异有统计学意义（P<0.05）。观察组患者用药后随访期间不良反应发生率为0，与对照组的2.44%比较，差异无统计学意义（P>0.05）。结论：康柏西普联合全视网膜激光光凝治疗可提高缺血型视网膜中央静脉阻塞伴黄斑水肿患者的视力，减少黄斑中心凹视网膜厚度。

【关键词】 康柏西普 全视网膜激光光凝 缺血型视网膜中央静脉阻塞 黄斑水肿 视力 黄斑中心凹视网膜厚度

Effects of Conbercept Combined with Pan-retinal Laser Photocoagulation on Visual Outcome and Retinal Thickness of Macular Fovea in Patients with Ischemic Central Retinal Vein Occlusion with Macular Edema/LI Binbin， TAN Meihua， YIN Zhangliang. //Medical Innovation of China， 2021， 18（32）： 019-022

[Abstract] Objective： To analyze the effects of Conbercept and pan-retinal laser photocoagulation in the treatment of patients with ischemic central retinal vein occlusion and macular edema， and provide a favorable reference for future treatment. Method： A total of 86 patients （86 eyes） with ischemic central retinal vein occlusion and macular edema who were admitted to our hospital from October 2016 to December 2020 were selected and divided into two groups according to the treatment method. The control group （n=41， 41 eyes） received 0.05 mL （0.5 mg） intravitreal injection of Conbercept; on the basis of the control group， the observation group （n=45， 45 eyes） received pan-retinal laser photocoagulation on the 7th day after the third injection. The patient’s best corrected visual acuity and the foveal retinal thickness of the patient’s macular foveal was measured 1， 2， 3 and 6 months after the treatment. Result： There were statistically significant differences between the best corrected visual acuity and CMT at different time points in the observation group （P<0.05）; there were statistically significant differences between the best corrected visual acuity and CMT at different time points in the control group （P<0.05）; 6 months after treatment， the CMT in the observation group was lower than that of the control group， the difference was statistically significant （P<0.05）. The incidence of adverse reactions in the observation group during the follow-up period after medication was 0， compared with 2.44% in the control group， the difference was not statistically significant （P>0.05）. Conclusion： Conbercept combined with pan-retinal laser photocoagulation can improve the visual acuity of patients with ischemic central retinal vein occlusion with macular edema and reduce the thickness of the foveal retina.

[Key words] Conbercept Pan-retinal laser photocoagulation Ischemic central retinal vein occlusion Macular edema Vision Thickness of retina in macular fovea

First-author’s address： Ganzhou People’s Hospital， Ganzhou 341000， China

doi：10.3969/j.issn.1674-4985.2021.32.005

视网膜中央静脉阻塞是一种致盲性眼病，伴黄斑水肿时治疗非常棘手，对患者视力损害较大，影响正常生活，且严重的缺血型患者视网膜毛细血管灌注较差，通常黄斑水肿程度严重，需要积极治疗，以改善视力[1]。药物治疗是常见的治疗方法，康柏西普是常用药物，在治疗黄斑水肿方面效果良好，而其联合激光治疗可有效避免复发，现报道如下。……