黄朝发 张榕华

摘 要 目的：探討瓜蒌皮注射液联合阿托伐他汀治疗冠心病的疗效和安全性。方法：选择2018年6月—2019年6月收治的120例冠心病患者，随机分为对照组和观察组各60例。对照组给予口服阿托伐他汀钙片治疗，20 mg/次，1次/d，共4周。观察组在此基础上加用瓜蒌皮注射液静脉滴注，1次/d，共4周。两组均随访6个月，比较两组疗效和安全性。结果：观察组总有效率为95.00%（57/60），高于对照组的81.67%（49/60，P<0.05）。治疗后，观察组每周心绞痛发作频率为（2.58±0.77）次，心绞痛发作持续时间每次为（2.15±0.44）min，分别低于对照组的（4.52±1.11）次和（4.71±0.97）min，组间差异有统计学意义（P<0.05）。观察组西雅图心绞痛量表（SAQ）评分为（85.06±8.79）分，高于对照组的（78.93±8.83）分（P<0.05）。两组治疗期间均未见明显药物不良反应。观察组在随访期间的心血管事件总发生率为5.00%（3/60），低于对照组的16.67%（10/60，P<0.05）。结论：瓜蒌皮注射液联合阿托伐他汀治疗冠心病疗效显著，安全性良好，值得临床推荐。

关键词 冠心病；瓜蒌皮注射液；阿托伐他汀；疗效；安全性

中图分类号：R541.4 文献标志码：A 文章编号：1006-1533（2021）04-0018-03

Evaluation of the efficacy and safety of Gualoupi injection combined with atorvastatin in the treatment of coronary heart disease

HUANG Chaofa， ZHANG Ronghua

（Internal Medicine-Cardiovascular Department of Guangxin District Peoples Hospital， Shangrao， Jiangxi 334100， China）

ABSTRACT Objective： To investigate the efficacy and safety of Gualoupi injection combined with atorvastatin in the treatment of coronary heart disease. Methods： One hundred and twenty patients with coronary heart disease admitted from June 2018 to June 2019 were selected and randomly divided into a control group and an observation group with 60 cases each. The control group was treated with oral atorvastatin calcium tablets， 20 mg/time， once daily for 4 weeks. On this basis， the observation group was given an intravenous drip of Gualoupi injection once daily for 4 weeks. Both groups were followed up for 6 months to compare their efficacy and safety. Results： The total effective rate was 95.00%（57/60） in the observation group， which was higher than 81.67% in the control group（49/60， P<0.05）； after treatment， the frequency of angina pectoris in the observation group was （2.58±0.77） times per week， and the duration of angina pectoris was （2.15±0.44） min each time， which were lower than those in the control group （4.52±1.11） and （4.71±0.97）， respectively. and the difference between groups was statistically significant（P<0.05）. The Seattle Angina Pectoris scale（SAQ） score in the observation group was （85.06±8.79） points， which was higher than the （78.93±8.83） points in the control group（P<0.05）. There were no obvious adverse drug reactions in the two groups during treatment. The total incidence of cardiovascular events in the observation group during the follow-up period was 5.00%（3/60）， which was lower than 16.67% in the control group（10/60， P<0.05）. Conclusion： Gualoupi injection combined with atorvastatin has significant efficacy and good safety in the treatment of coronary heart disease， and is worthy of clinical recommendation.

KEY WORDS coronary heart disease； Gualoupi injection； atorvastatin； efficacy； safety

冠心病是临床常见的心脏疾病。阿托伐他汀是治疗冠心病的常用药物，能够有效抑制动脉粥样硬化形成，改善患者心绞痛症状[1]。但临床实践表明，单独使用阿托伐他汀治疗冠心病疗效仍难以达到理想状态[2]。瓜蒌皮注射液为中成药制剂，有扩张冠状动脉、改善血液流变学、增加冠状动脉血流量等作用[3]。本文报道用瓜蒌皮注射液联合阿托伐他汀治疗冠心病的效果。

1 资料与方法

1.1 一般资料

选择我院2018年6月—2019年6月进行治疗的120例冠心病患者，均经心电图及冠状动脉造影等常规检查明确诊断，入选前3个月内未发生过急性冠脉综合征或急性心肌梗死。按照随机数字表对照法将患者分为观察组和对照组各60例。观察组中男性35例，女性25例，年龄为36～76岁，平均年龄为（54.13±7.85）岁，病程2～7年，平均（3.13±0.95）年；心绞痛Ⅱ级40例，Ⅲ级20例。对照组中男性35例，女性25例，年龄为36～77岁，平均年龄为（54.22±7.79）岁，病程2～7年，平均（3.17±0.97）年；心绞痛Ⅱ级41例，Ⅲ级19例。两组患者的基线资料相比差异无统计学意义（P>0.05）。排……