江经正 陈冰灵 柯步举 刘楚永 杨锐群

[摘要] 目的 探讨特布他林联合布地奈德治疗慢性阻塞性肺疾病患者的有效性及对患者血清CRP、TNF-α水平的影响。 方法 选取2019年1—12月因慢性阻塞性肺疾病来我院接受治疗的104例患者为研究对象，随机分为研究组与对照组。对照组予布地奈德治疗，研究组在对照组基础上联合特布他林治疗。比较两组疗效及不良反应情况、治疗前后的炎症因子水平、肺功能指标以及治疗前后的生活质量水平。 结果 研究组總有效率高于对照组，差异有统计学意义（P<0.05），两组不良反应情况发生率比较，差异无统计学意义（P>0.05）;研究组治疗后的CRP、TNF-α指标均低于对照组，差异有统计学意义（P<0.05）;研究组各项肺功能指标均高于对照组，差异有统计学意义（P<0.05）;与对照组治疗后相比，研究组社会、躯体、角色及认知功能评分均较高，差异有统计学意义（P<0.05）。 结论 对慢阻肺患者采用布地奈德与特布他林联合治疗，其治疗效果较好，安全性较高，能够有效降低患者的CRP及TNF-α水平，抑制机体炎症反应，改善其肺功能，临床应用价值较高。

[关键词] 慢性阻塞性肺疾病;特布他林;布地奈德;C-反应蛋白

[中图分类号] R563.9          [文献标识码] B          [文章编号] 1673-9701（2021）36-0060-04

The effectiveness of terbutaline combined with budesonide in patients with chronic obstructive pulmonary disease and its effect on serum CRP and TNF-α levels

JIANG Jingzheng1   CHEN Bingling2   KE Buju1   LIU Chuyong1   YANG Ruiqun1

1.The Fifth Department of Internal Medicine， the Second People's Hospital of Shantou，Guangdong Province， Shantou   515000， China; 2.The Fourth Department of Internal Medicine， the Second People's Hospital of Shantou， Guangdong Province， Shantou   515000， China

[Abstract] Objective To investigate the effectiveness of terbutaline combined with budesonide in patients with chronic obstructive pulmonary disease and its effect on serum CRP and TNF-α levels. Methods A total of 104 patients with chronic obstructive pulmonary disease treated in our hospital from January to December 2019 were selected as the research objects. They were randomly divided into the study group and the control group. The control group was treated with budesonide. The study group was treated with terbutaline based on the treatment of the control group. The efficacy and adverse conditions， the levels of inflammatory factors， lung function indicators， and the level of quality of life before and after treatment of the two groups were compared. Results The total effective rate of the study group was higher than that of the control group， and the difference was statistically significant （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. The CRP and TNF-α of the study group after treatment were lower than those of the control group， and the difference was statistically significant（P<0.05）. The lung function indicators of the study group were higher than that of the control group， and the difference was statistically significant（P<0.05）. Compared with the control group after treatment， the social， physical， role and cognitive function scores of the study group were higher， and the difference was statistically significant（P<0.05）. Conclusion The combined treatment of budesonide and terbutaline in patients with COPD has a good therapeutic effect and high safety. It can effectively reduce the levels of CRP and TNF-α in patients， inhibit the body's inflammatory response， improve their lung function， and has a high clinical application value.

[Key words] COPD; Terbutaline; Budesonide; C-reactive protein

在中老年患者中，慢性阻塞性肺疾病（以下简称“慢阻肺”）的发病率相对较高，为常见的呼吸系统疾病，剧烈喘息以及咳嗽有痰等是该疾病的主要临床表现，病情严重者伴有呼吸不畅，严重影响患者的日常生活及身体健康[1]。在以往的临床治疗中，主要通过药物治疗、氧疗、早期干预以及呼吸康复等对慢阻肺患者进行治疗，但其治疗效果并不理想[2]。……