黄伟 江智春 张海军 刘斌斌 李青峰

摘 要 目的：探讨盐酸氨基葡萄糖胶囊联合塞来昔布治疗膝骨关节炎的临床效果。方法：采用前瞻性随机试验方法，将85例膝骨关节炎患者作为研究对象随机分为对照组（n=43）和观察组（n=42）。对照组口服塞来昔布治疗，观察组口服盐酸氨基葡萄糖胶囊联合塞来昔布治疗。比较两组治疗3个月后临床疗效、治疗前及治疗3个月结束时炎性因子水平，统计两组治疗期间不良反应发生情况。结果：治疗3个月结束时，观察组总有效率高于对照组（95.24% vs 76.74%）；两组血清TNF-a、IL-1b、IL-6低于治疗前，观察组低于对照组（均P<0.05）；治疗期间，观察组不良反应发生率差异无统计学意义（P>0.05）。结论：盐酸氨基葡萄糖胶囊联合塞来昔布可减轻膝骨关节炎患者炎症反应，效果显著，且未增加不良反应。

关键词 膝骨关节炎 盐酸氨基葡萄糖胶囊 塞来昔布 炎性因子 不良反应

中图分类号：R977.6； R684.3 文献标志码：B 文章编号：1006-1533（2021）23-0049-03

Clinical study of glucosamine hydrochloride capsules combined with celecoxib in the treatment of knee osteoarthritis

HUANG Wei， JIANG Zhichun， ZHANG Haijun， LIU Binbin， LI Qingfeng

（Department I of Bone Injury， Chinese Medicine Hospital of Xinfeng County， Ganzhou 341600， China）

ABSTRACT Objective： To investigate the clinical effect of glucosamine hydrochloride capsule combined with celecoxib in the treatment of knee osteoarthritis. Methods： Eighty-five patients with knee osteoarthritis were randomly divided into a control group （n=43） and an observation group （n=42）. The control group was treated with oral celecoxib， and the observation group was treated with oral glucosamine hydrochloride capsule combined with celecoxib. The clinical efficacy， the levels of inflammatory factors before treatment and at the end of 3 months of treatment and the incidence of adverse reactions during the treatment were compared between the two groups. Results： At the end of three months， the overall response rate was higher in the observation group than the control group （95.24% vs 76.74%）. The serum levels of TNF-a， IL-1b and IL-6 in the two groups were lower after treatment than before， and furthermore were lower in the observation group than the control group （all P<0.05）. There were no significant differences between the two groups in the incidence of adverse reactions during the treatment （P>0.05）. Conclusion： Glucosamine hydrochloride capsules combined with celecoxib can reduce the inflammatory reaction of patients with knee osteoarthritis with significant effect and without increase in the incidence of adverse reactions.

KEY WORDS knee osteoarthritis； glucosamine hydrochloride capsules； celecoxib； inflammatory factor； adverse reaction

膝骨關节炎在中老年人群中发病率较高，不仅给患者带来疼痛，还对膝关节功能造成影响，导致患者丧失劳动力。目前治疗膝骨关节炎主要以缓解疼痛、预防继发损伤为目的。口服药物中塞来昔布为环氧化酶-2抑制剂，被广泛应用于膝骨关节炎的治疗，虽然可减轻局部疼痛，但无法对膝骨关节炎病理起到改变作用[1]。而盐酸氨基葡萄糖胶囊不仅能够使关节软骨合成增加，还能抑制其破坏，保护膝关节[2]。鉴于此，本研究就盐酸氨基葡萄糖胶囊联合塞来昔布治疗膝骨关节炎的临床效果作以下分析。……