刘文耀 包伟 谢杰

【摘要】 目的：观察定喘汤合止嗽散治疗咳嗽变异性哮喘的临床效果。方法：选取2016年1月-2019年1月于笔者所在医院门诊就诊的72例咳嗽变异性哮喘患者，根据随机数字表法分为对照组和观察组，各36例。对照组予以常规西医治疗，观察组在对照组基础上予以定喘汤合止嗽散治疗，评估两组临床效果及随访6个月内复发率。结果：观察组总有效率为91.67%，高于对照组的72.22%，差异有统计学意义（P<0.05）;随访6个月，观察组复发率为8.33%，低于对照组的27.78%，差异有统计学意义（P<0.05）。结论：定喘汤合止嗽散对咳嗽变异性哮喘疗效确切，且复发率较低，值得在临床中推广应用。

【关键词】 咳嗽变异性哮喘 定喘汤合止嗽散 常规西医治疗 疗效

doi：10.14033/j.cnki.cfmr.2020.13.057 文献标识码 B 文章编号 1674-6805（2020）13-0-03

Clinical Effect of Dingchuan Decoction Combined with Zhisou Powder on Cough Variant Asthma/LIU Wenyao， BAO Wei， XIE Jie. //Chinese and Foreign Medical Research， 2020， 18（13）： -141

[Abstract] Objective： To observe the clinical effect of Dingchuan Decoction combined with Zhisou Powder on cough variant asthma. Method： A total of 72 patients with cough variant asthma who visited the outpatient department of our hospital from January 2016 to January 2019 were selected and divided into the control group and the observation group according to the random number table method， 36 cases in each group. The control group was treated with conventional western medicine， and the observation group was treated with Dingchuan Decoction combined with Zhisou Powder on the basis of the control group. The clinical effect and recurrence rate within 6 months of follow-up were evaluated between the two groups. Result： The total effective rate of the observation group was 91.67%， which was higher than 72.22% of the control group， and the difference was statistically significant （P<0.05）. Within 6 months of follow-up， the recurrence rate of the observation group was 8.33%， which was lower than 27.78% of the control group， and the difference was statistically significant （P<0.05）. Conclusion： Dingchuan Decoction combined with Zhisou Powder has a definite therapeutic effect on cough variant asthma， and the recurrence rate is lower， which is worthy of clinical application.

[Key words] Cough variant asthma Dingchuan Decoction combined with Zhisou Powder Conventional western medicine treatment Curative effect

First-authors address： Fujian Normal University Hospital， Fuzhou 350007， China

咳嗽變异性哮喘（CVA）又称过敏性哮喘或隐匿性哮喘，以≥8周的慢性咳嗽为唯一或主要的临床表现[1]。咳嗽变异性哮喘属于中医“咳嗽”范畴，近年来其发病率逐年上升。林洁等[2]研究发现，在慢性咳嗽的病因中CVA可占43.67%。咳嗽变异性哮喘以夜间及凌晨的剧烈刺激性干咳为主要临床特征，常影响患者夜间睡眠质量及次日的学习、工作等社会活动。部分咳嗽变异性哮喘患者甚至会发展为典型的哮喘，严重降低生活质量。咳嗽变异性哮喘的西医治疗原则与典型哮喘基本相同，常规的西药包括吸入性糖皮质激素（ICS）、口服糖皮质激素、支气管舒张剂、白三烯受体拮抗剂等[3]。中医治疗以疏风宣肺、止咳平喘为基本原则。近年来，笔者采用定喘汤合止嗽散治疗咳嗽变异性哮喘取得了较好的临床效果，报道如下。

1 资料与方法

1.1 一般资料

选取2016年1月-2019年1月于笔者所在医院门诊就诊的72例咳嗽变异性哮喘患者作为研究对象，均为福建师范大学教师员工（含在职和离退休教师员工）和学生。……