尹婷婷

【摘 要】 目的：讨论在儿童甲状腺功能亢进症患儿的临床治疗过程中应用甲巯咪唑、左甲状腺素联合疗法进行治疗的临床应用价值。方法：筛选出2017年6月至2019年6月于我院进行治疗的甲状腺功能亢进症患儿86例，应用数字随机表将符合纳入标准的患儿随机划分为参照组与观察组。参照组应用甲巯咪唑疗法，观察组应用甲巯咪唑、左甲状腺素联合疗法。结果：相较于参照组，观察组的临床诊治有效性明显提升20.93%（P<0.05）;观察组的不良反应发生率明显缩减11.63%（P<0.05）。结论：在儿童甲状腺功能亢进症患儿的临床治疗过程中应用甲巯咪唑、左甲状腺素联合疗法进行治疗，能够有效缓解患儿的临床症状，且安全系数较高。

【关键词】 甲巯咪唑;左甲状腺素;儿童甲状腺功能亢进症;临床疗效

Abstract：Objective：Discuss the clinical application value of the combination of methimazole and levothyroxine in the clinical treatment of children with hyperthyroidism. Method：Eighty-six children with hyperthyroidism who were treated in our hospital from June 2017 to June 2019 were screened. The children who met the inclusion criteria were randomly divided into the reference group and the observation group. The reference group was treated with methimazole therapy， and the observation group was treated with methimazole and levothyroxine. Result：Compared with the reference group， the clinical diagnosis and treatment effectiveness of the observation group was significantly increased by 20.93% （P<0.05）; the incidence of adverse reactions in the observation group was significantly reduced by 11.63% （P<0.05）. Conclusion：In the clinical treatment of children with hyperthyroidism in children， the combination of methimazole and levothyroxine combined therapy can effectively alleviate the clinical symptoms of children， and the safety factor is high.

Key words：methimazole; levothyroxine; hyperthyroidism in children; clinical efficacy

甲状腺功能亢进症是一种临床上较为常见的儿科疾病，患儿的临床表征主要为进食频率增大、排便频次增多、体质量下降、出汗等症状，部分患儿还伴随视力衰减症状，对患儿的正常生活及身心健康具有严重的不良影响[1-2]。本次研究将着重讨论在儿童甲状腺功能亢进症患儿的临床治疗过程中应用甲巯咪唑、左甲状腺素联合疗法进行治疗的临床应用价值。现将结果报道如下。

1 资料与治疗措施

1.1 一般资料

筛选出2017年6月至2019年6月于我院进行治疗的甲状腺功能亢进症患儿86例，应用数字随机表将符合纳入标准的患儿随机划分为参照组与观察组，例数均为43例。参照组中男女患儿例数之比为22：21，年龄平均为（5.39±1.29）岁;观察组中男女患儿例数之比为23：20，年龄平均为（5.28±1.42）岁。入选患儿均经相關诊断标准被确诊为儿童甲状腺功能亢进症，且不存在先天性智力障碍疾病。

1.2 治疗方法

参照组应用甲巯咪唑疗法，给药方式为口服，给药剂量为0.4mg/（kg·d），每日三次。……