曹颖 蔡伟雄 曾连英 陈惠娟

[摘要] 目的 探討血清降钙素原（PCT） 、C反应蛋白（CRP）及白细胞计数（WBC）对儿童早期感染性疾病的诊断价值。方法 简单随机选取2018年12月—2019年8月期间该院收治的100例早期细菌感染患儿作为细菌感染组，另选择同期在该院治疗的50例非细菌感染患儿作为非细菌感染组，另择取同期在该院体检的50名健康儿童作为对照组。统计非细菌感染组和细菌感染组患儿治疗前、治疗48 h后和出院前PCT、WBC、CRP指标水平，并与对照组患儿对比，同时分析各组治疗期间指标变化。结果 PCT监测发现：非细菌感染组治疗前、治疗48 h后、出院时PCT水平均显著低于细菌感染组，差异有统计学意义（P<0.05）。CRP监测发现：非细菌感染组和细菌感染组治疗后CRP指标均显著下降（P<0.05），但非细菌感组治疗前、治疗48 h后、出院时CRP水平[（7.03±5.25） ng/mL、（4.03±1.58） ng/mL、（2.03±0.85）ng/mL]均显著低于细菌感染组，差异有统计学意义（P<0.05）。WBC监测发现：非细菌感染组治疗前、治疗48 h后、出院时WBC水平[（7.01±1.86）×109/L、（6.54±0.96）×109/L、（6.36±0.58）×109/L]均显著低于细菌感染组，差异有统计学意义（P<0.05）。结论 儿童早期感染性疾病患儿PCT、WBC、CRP指标水平存在一定特征性的变化，可为细菌感染诊断提供一定参考依据，诊断价值较高。

[关键词] PCT;WBC;CRP;儿童;早期

[中图分类号] R4          [文献标识码] A          [文章编号] 1674-0742（2020）06（a）-0184-03

Diagnostic Value of PCT， WBC and CRP in Early Childhood Infectious Diseases

CAO Ying， CAI Wei-xiong， ZENG Lian-ying， CHEN Hui-juan

Department of Laboratory Medicine， People's Hospital of Boluo County， Boluo， Guangdong Province， 516100 China

[Abstract] Objective To investigate the diagnostic value of serum procalcitonin （PCT）， C-reactive protein （CRP） and white blood cell count （WBC） in early childhood infectious diseases. Methods A total of 100 children with early bacterial infections treated in the hospital from December 2018 to August 2019 were convenienty randomly selected as the bacterial infection group， and 50 non-bacterial infection children treated in our hospital during the same period were selected as the non-bacterial infection group. Fifty healthy children who underwent physical examination in our hospital during the same period were selected as the control group. The PCT， WBC， and CRP levels of the children in the non-bacterial infection group and the bacterial infection group were counted before treatment， after 48 h of treatment， and before discharge from the hospital， and compared with those in the control group. At the same time， the changes of the indicators during the treatment were analyzed. Results PCT monitoring showed that the PCT level in the non-bacterial infection group was significantly lower than that in the bacterial infection group before treatment， 48 h after treatment， and at discharge， with a significant difference （P<0.05）. CRP monitoring showed that the CRP index of the non-bacterial infection group and the bacterial infection group decreased significantly after treatment （P<0.05）， but the CRP [（7.03 ± 5.25）ng/mL， （4.03±1.58）ng/mL， （2.03 ± 0.85）ng/mL] were significantly lower than those in the bacterial infection group， and the difference was statistically significant （P<0.05）. WBC monitoring found： before treatment， 48 h after treatment， non-bacterial infection group WBC [（7.01 ± 1.86）×109/L， （6.54±0.96）×109/L，（6.36±0.58）×109/L] level was significantly lower than the bacterial infection group， and the difference was statistically significant （P<0.05）. Conclusion There are some characteristic changes in the levels of PCT， WBC and CRP in children with infectious diseases in early childhood， which can provide a certain reference for the diagnosis of bacterial infection and have higher diagnostic value.

[Key words] PCT; WBC; CRP; Children; Early

感染性疾病是儿科最常见的疾病，10岁以下儿童的发病率尤其高，约60%以上的儿科疾病属于感染性疾病[1-2]。儿童感染性疾病的病因复杂，且进展速度较快，尽早确诊是改善患儿预后的重要条件，为此应进一步提高早期感染性疾病诊断水平[3-4]。实验室检查指标是初步评估患儿感染情况的重要指标，具有高效、准确、快捷、可重复检测等优点，其中PCT、WBC、CRP是较为灵敏的炎症反应指标，在感染性疾病早期诊断与治疗后评估中应用较多，为进一步探明其对儿童早期感染性疾病的诊断价值，该次研究简单随机选取2018年12月—2019年8月期间该院收治的100例早期细菌感染患儿、50例非细菌感染患儿和50名健康儿童作为研究对象，总结、分析了不同受试者的指标特征，现报道如下。……