金雁　肖新益

【摘要】 目的：探讨保妇康栓联合重组人干扰素α2b栓对慢性宫颈炎患者临床疗效与不良反应的影响。方法：选择2018年3月-2019年9月笔者所在医院收治的慢性宫颈炎患者98例，根据盲抽法分为观察组和对照组，各49例。对照组给予重组人干扰素α2b栓治疗，观察组在对照组基础上给予保妇康栓治疗。3个月经周期为1个疗程，两组均治疗1个疗程。比较两组治疗后临床疗效、不良反应发生率。结果：治疗后，观察组总有效率（87.76%）显著高于对照组（69.39%），差异有统计学意义（P<0.05）。观察组不良反应发生率为6.12%，略低于对照组的12.24%，差异无统计学意义（P>0.05）。结论：对慢性宫颈炎患者应用保妇康栓联合重组人干扰素α2b栓可提高临床疗效，且未增加不良反应，安全性较高。

【关键词】 慢性宫颈炎 保妇康栓 重组人干扰素α2b栓 不良反应

doi：10.14033/j.cnki.cfmr.2020.18.059 文献标识码 B 文章编号 1674-6805（2020）18-0-02

Application of Baofukang Suppository Combined with Recombinant Human Interferon α2b in Chronic Cervicitis/JIN Yan， XIAO Xinyi. //Chinese and Foreign Medical Research， 2020， 18（18）： -139

[Abstract] Objective： To investigate the effects of Baofukang Suppository combined with Recombinant Human Interferon α2b on the clinical effect and adverse reaction of chronic cervicitis patients. Method： A total of 98 patients with chronic cervicitis were selected from March 2018 to September 2019 in our hospital， which were divided into the observation group and the control group according to blind extraction， 49 cases in each group. The control group was treated with Recombinant Human Interferon α2b. On the basis of the control group， the observation group was treated with Baofukang Suppository. The 3 menstrual cycles were 1 course of treatment， and both groups were treated 1 course of treatment. The clinical effect and the incidence of adverse reactions after treatment were compared between the two groups. Result： After treatment， the total effective rate of the observation group was 87.76%， which was higher than 69.39% of the control group， and the difference was statistically significant （P<0.05）. The incidence of adverse reactions in the observation group was 6.12%， which was slightly lower than 12.24% of the control group， but the difference was not statistically significant （P>0.05）. Conclusion： Treatment of chronic cervicitis patients with Baofukang Suppository combined with Recombinant Human Interferon α2b can improve the clinical efficacy， and did not increase adverse reactions， and with high safety.

[Key words] Chronic cervicitis Baofukang Suppository Recombinant Human Interferon α2b Adverse reaction

First-authors address： Huangshi Aikang Hospital， Huangshi 435000， China

慢性宮颈炎是妇科常见疾病，常因急性宫颈炎治疗不彻底导致病原体藏于宫颈黏膜内所致。近年来，慢性宫颈炎发病率逐渐增高，多于分娩、流产、手术损伤宫颈后发病。患者主要临床表现为月经不规律、白带增多、痛经等，若不及时治疗，可能会发展成宫颈癌，严重影响患者的身心健康[1]。目前，临床多采用激光、药物、微波等方式治疗慢性宫颈炎。重组人干扰素α2b栓能有效改善炎症状况，但患者易出现下腹坠胀等不良反应。随着中医的发展，保妇康栓开始广泛应用于慢性宫颈炎治疗中，具有清热解毒、活血化瘀之功效，可有效提高临床效果[2]。鉴于此，本研究旨在探讨保妇康栓联合重组人干扰素α2b栓对慢性宫颈炎患者的临床疗效与不良反应发生，报道如下。……