邹弟勇

【摘要】 目的：探讨不同锌制剂治疗小儿抗生素相关性腹泻（AAD）及预防复发的效果。方法：选取笔者所在医院于2017年10月-2019年10月收诊的122例AAD患儿。按照等距抽样法将其分为对照组（61例）和观察组（61例）。对照组给予葡萄糖酸锌治疗，观察组给予锌硒制剂治疗。比较两组腹泻时间、呕吐时间、发热时间及腹泻复发率。结果：观察组腹泻时间（3.13±0.47）d，呕吐时间（1.79±0.35）d，发热时间（2.47±0.35）d，均短于对照组，差异有统计学意义（P<0.05）。观察组腹泻复发率为4.92%，低于对照组的18.03%，差异有统计学意义（P<0.05）。结论：应用锌硒制剂可改善AAD患儿临床症状，降低腹泻复发率，值得应用。

【关键词】 腹泻 抗生素 小儿 锌制剂

doi：10.14033/j.cnki.cfmr.2020.18.055 文献标识码 B 文章编号 1674-6805（2020）18-0-02

Comparative Observation of the Effect of Different Zinc Preparations in the Treatment of Antibiotic-associated Diarrhea and Prevention of Recurrence in Children/ZOU Diyong. //Chinese and Foreign Medical Research， 2020， 18（18）： -130

[Abstract] Objective： To explore the effect of different zinc preparations in the treatment of antibiotic-associated diarrhea （AAD） and prevention of recurrence in children. Method： A total of 122 children with AAD admitted in our hospital from October 2017 to October 2019 were selected. They were divided into the control group （61 cases） and the observation group （61 cases） by isometric sampling method. The control group was treated with Zzinc Gluconate， and the observation group was treated with Zinc Selenium Preparations. The diarrhea time， vomiting time， fever time and recurrence rate of diarrhea were compared between the two groups. Result： The diarrhea time （3.13±0.47） d， vomiting time （1.79±0.35） d， fever time （2.47±0.35） d in the observation group were all shorter than those in the control group， the differences were statistically significant （P<0.05）. The recurrence rate of diarrhea in the observation group was 4.92%， which was lower than 18.03% in the control group， and the difference was statistically significant （P<0.05）. Conclusion： The application of zinc selenium preparations can improve the clinical symptoms and reduce the recurrence rate of diarrhea in children with AAD， which is worthy of application.

[Key words] Diarrhea Antibiotics Children Zinc preparations

First-authors address： Tongcheng Maternal and Child Health Hospital， Tongcheng 437400， China

抗生素相关性腹泻（AAD）多發群体为5岁以下儿童[1]，一般为抗生素用药后不良反应所致[2]，用药不合理可能会促使患儿产生脱水、发热及肠鸣音减弱等问题，进而影响其恢复[3]。各医疗机构为减少AAD患儿的上述问题，以锌硒制剂替代葡萄糖酸锌对其进行诊治。本文探讨了锌硒制剂应用于AAD患儿中的效果，现报道如下。

1 资料与方法

1.1 一般资料

选取笔者所在医院于2017年10月-2019年10收诊的AAD患儿122例，纳入标准：（1）符合《腹泻病诊断治疗指南》中关于AAD的标准[4];（2）患儿相关临床资料齐全。排除标准：（1）年龄>3岁;（2）患儿家属的理解、表达能力不佳。按照等距抽样法将其分为对照组（61例）、观察组（61例）。观察组中女30例，男31例;年龄8个月～3岁，平均（1.86±0.33）岁;抗生素应用：阿奇霉素9例，头孢替唑钠10例，头孢唑林钠12例，头孢呋辛钠13例，红霉素17例。对照组中女29例，男32例;年龄7个月～3岁，平均（1.95±0.31）岁;抗生素应用：阿奇霉素9例，头孢替唑钠9例，头孢唑林钠11例，头孢呋辛钠14例，红霉素18例。两组一般资料比较差异无统计学意义（P>0.05），有可比性。患儿……