夏吉星

【摘要】 目的：分析丹紅注射液治疗急性脑梗死患者的临床效果。方法：选取2015年1月-2018年1月笔者所在医院收治的急性脑梗死患者84例，将行溶栓、扩血管、抗凝、脱水等常规治疗患者设为对照组（42例），将行常规治疗联合丹红注射液治疗患者设为观察组（42例），比较两组神经功能缺损情况[美国国立卫生院神经功能缺损评分法（NIHSS）]、血液流变学变化情况、肝肾功能及不良反应发生率。结果：治疗前两组NIHSS评分、血液流变学指标比较，差异均无统计学意义（P>0.05）;两组治疗后NIHSS评分均较治疗前下降，且观察组低于对照组（P<0.05）;观察组治疗后红细胞比容、血浆比黏度、全血比黏度高切、全血比黏度低切均较治疗前下降，且均低于对照组（P<0.05）;两组治疗后纤维蛋白原比较，差异无统计学意义（P>0.05）;观察组治疗后总有效率为92.86%，显著高于对照组的71.43%（P<0.05）;观察组不良反应发生率为11.90%，与对照组的14.29%比较，差异无统计学意义（字2=0.759，P>0.05）;两组肝肾功能均未见异常。结论：丹红注射液是治疗急性脑梗死的安全有效的药物，可在临床中推广应用。

【关键词】 急性脑梗死 丹红注射液 疗效 神经功能

doi：10.14033/j.cnki.cfmr.2020.18.021 文献标识码 B 文章编号 1674-6805（2020）18-00-04

Effect of Danhong Injection on Acute Cerebral Infarction/XIA Jixing. //Chinese and Foreign Medical Research， 2020， 18（18）： -52

[Abstract] Objective： To analyze the clinical efficacy Danhong Injection on patients with acute cerebral infarction. Method： Eighty-four patients with acute cerebral infarction admitted to our hospital from January 2015 to January 2018 were selected. The patients who received routine treatments such as thrombolysis， vasodilation， anticoagulation and dehydration were set as the control group （42 cases）， and the patients who received routine treatment combined with Danhong Injection were set as the observation group （42 cases）. The situation of neurological function deficiency [National Institute of health stroke scale （NIHSS）]， changes of hemorheology， liver and kidney function and incidence of adverse reactions were compared between the two groups. Result： Before treatment， NIHSS scores and hemorheology indexes were compared between the two groups， and the differences were not statistically significant （P>0.05）. After treatment， NIHSS scores in both groups decreased compared with those before treatment， and the observation group was lower than that of the control group （P<0.05）. After treatment， hematocrit， specific viscosity of plasma， whole blood specific viscosity high cut and whole blood specific viscosity low cut in the observation group decreased compared with those before treatment， and the observation group were lower than those of the control group （P<0.05）. The fibrinogen was compared between the two groups， and the difference was not statistically significant （P>0.05）. The total effective rate in the observation group was 92.86%， which was significantly higher than 71.43% of the control group （P<0.05）. The incidence of adverse reactions in the observation group was 11.90%， compared with 14.29% of the control group， and the difference was not statistically significant （P>0.05）. There were no abnormalities in liver and kidney function in the two groups. Conclusion： Danhong Injection is safe and effective in the treatment of acute cerebral infarction and can be widely used in clinical practice.

[Key words] Acute cerebral infarction Danhong Injection Effect Neurological function

First-authors address： The First Peoples Hospital of Xianning， Xianning 437100， China

急性脑梗死是一种较为常见的多发病，具有较高的致残、致死率。近年来，随着人们饮食结构及作息习惯的改变，急性脑梗死发病率呈逐年上升趋势，且发病人群趋于年轻化，若不及时进行有效治疗，可给患者大脑造成严重损伤。由于脑损伤具有不可逆性，因而会明显降低患者的生活质量[1]。对急性脑梗死患者治疗的关键是尽早恢复缺血区的血液供应。临床研究发现，丹红注射液具有改善血液循环的作用[2]。鉴于此，笔者所在医院对急性脑梗死患者采用丹红注射液进行治疗，效果较好，总结如下。

1 资料与方法

1.1 一般资料

选取2015年1月-2018年1月于笔者所在医院进行治疗的急性脑梗死患者84例。纳入……