周海军 廖丽君 李红梅

[摘要]目的 分析異位妊娠患者凝血功能指标及相关因子检测结果。方法 选取我院2017年10月～2019年3月收治的50例异位妊娠患者作为观察组，选取同期来我院进行正常产检的50例宫内妊娠者作为对照组。比较两组的子宫内膜厚度（EST）水平、凝血功能各指标、人绒毛膜促性腺激素（β-HCG）、孕酮（P）水平。结果 观察组的EST水平低于对照组，差异有统计学意义（P<0.05）;观察组的纤维蛋白原（FIB）水平低于对照组，活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）时间长于对照组，差异有统计学意义（P<0.05）;观察组的β-HCG、P水平均低于对照组，差异有统计学意义（P<0.05）。结论 异位妊娠患者凝血功能指标有明显的变化，而且其β-HCG、P水平和正常宫内妊娠有明显差异，临床可通过这些指标的检测辅助临床诊断。

[关键词]异位妊娠;凝血功能;相关因子;检测结果

[中图分类号] R446.11          [文献标识码] A          [文章编号] 1674-4721（2020）7（c）-0142-03

Analysis of detection results of coagulation function and related factors in patients with ectopic pregnancy

ZHOU Hai-jun1   LIAO Li-jun2   LI Hong-mei1

1. Department of Clinical Laboratory， Xinyu Maternal and Child Health Hospital of Jiangxi Province， Xinyu   338025， China; 2. Department of Obstetrics and Gynecology， Xinyu Maternal and Child Health Hospital of Jiangxi Province， Xinyu   338025， China

[Abstract] Objective To analyze the detection results of coagulation function indexes and related factors in patients with ectopic pregnancy. Methods A total of 50 cases of ectopic pregnancy admitted to our hospital from October 2017 to March 2019 were selected as the observation group， and 50 cases of intrauterine pregnancy who came to our hospital for normal labor examination at the same time were selected as the control group. The levels of endometrial stripe thickness （EST）， coagulation function index， human chorionic gonadotropin （β-HCG） and progesterone （P） were compared between the two groups. Results The level of EST in the observation group was lower than that in the control group， the difference was statistically significant （P<0.05）. The level of fibrinogen （FIB） in the observation group was lower than that in the control group， the activated partial thromboplastin time （APTT）， prothrombin time （PT） and thrombin time （TT） in the observation group were longer than those in the control group， the differences were statistically significant （P<0.05）. The levels of β-HCG and P in the observation group were lower than those in the control group， the differences were statistically significant （P<0.05）. Conclusion There are obvious changes in coagulation function indexes of ectopic pregnancy patients， and there are significant differences in β-HCG， P levels and normal intrauterine pregnancy， clinical diagnosis can be assisted by the detection of these indicators.

[Key words] Ectopic pregnancy; Coagulation function; Related factors; Detection results

异位妊娠（EP）是妇产科常见急腹症，其发病原因与患者单侧或双侧输卵管管腔及其周围炎症有一定的关系，使得受精卵不能够正常通过，导致机体出现EP[1-2]。现阶段，EP的发病率有上升的趋势，约有1/3的患者会发生大出血休克，严重威胁患者的生命。EP患者的临床表现为急性剧烈腹痛，严重者可休克，甚至危及生命[3-4]。EP的发病原因较多，一般认为，其发病和输卵管炎症、输卵管手术、输卵管发育不良、受精卵游走、辅助生育技术等因素有关，当然，子宫肌瘤、卵巢肿瘤卵巢周围组织的粘连等也会增加EP的发生。有研究指出，EP患者孕囊未破裂时，机体即呈现高凝状态倾向[5-6]。因此，本研究分析EP患者凝血功能指标及相关因子的检测情况，旨在利于辅助临床积极诊治，现报道如下。

1资料与方法

1.1一般资料

选取我院2017年10月～2019年3月收治的50例EP患者作为观察组，年龄24～39岁，平均（30.46±4.22）岁;停经时间46～81 d，平均（60.48±7.24）d;EP类型：输卵管壶腹部妊娠39例，输卵管峡部妊娠6例，输卵管伞部妊娠5例。……