郑晓

【摘 要】目的：探究白蛋白（ALB）相关生化指标检验在糖尿病合并肝硬化老年患者中的临床意义。方法：于2017年1月--2019年10月，选取糖尿病合并肝硬化老年患者120例，回顾性分析其全部的临床资料，所有患者均接受相应治疗，并于治疗前、后1w、2w、3w测定血清PA（前白蛋白）、ALB等水平，测定方法分别为免疫比浊法和溴甲酚氯法，并对患者疗效进行评估。结果：，本组120例患者经治疗后1w的无效103例，有效17例;2w的无效者81例、有效者39例;3w的无效者36例、有效者84例。患者治疗前、后的ALB水平对比未表现出差异，P>0.05，说明无统计学价值;而同治疗前、后1w相比，治疗后2w、3w的PA水平明显增高，对比发现P<0.05，说明存在统计学价值。結论：临床检验白蛋白相关生化指标如PA、ALB等有利于对糖尿病合并肝硬化老年患者疗效进行评估，因此值得推广研究。

【关键词】老年;糖尿病合并肝硬化;白蛋白;生化指标;临床检验

Abstract：Objective To explore the clinical significance of albumin （ALB） -related biochemical indicators in elderly patients with diabetes and liver cirrhosis. Methods： From January 2017 to October 2019， 120 elderly patients with diabetes and liver cirrhosis were selected， and all clinical data were retrospectively analyzed. All patients received corresponding treatment， and before and after treatment 1w， 2w， The serum PA （prealbumin） and ALB levels were measured at 3w. The determination methods were immunoturbidimetric method and bromocresol chloride method， and the efficacy of the patients was evaluated. Results： After treatment， 120 patients in this group had 103 invalid cases and 17 effective cases; 81 cases had 2 cases of ineffective cases and 39 cases had effective cases; 36 cases had 3 cases of ineffective cases and 84 cases had effective cases. The comparison of ALB levels before and after treatment showed no difference， P> 0.05， indicating no statistical value; compared with 1w before and after treatment， PA levels increased significantly at 2w and 3w after treatment， and it was found that P <0.05 ， Indicating that there is statistical value. Conclusion： The clinical examination of albumin-related biochemical indicators such as PA and ALB is helpful to evaluate the efficacy of elderly patients with diabetes and liver cirrhosis， so it is worthy of popularization and research.

Key words： elderly; diabetes with liver cirrhosis; albumin; biochemical indicators; clinical tests

近几年，由于人们生活节奏的加快以及饮食结构的转变，临床上发生糖尿病的不断增多，而该病症的高发人群即为老年人。同时作为肝炎大国，我国的乙型肝炎等发病率明显高于国际水平[1]。持续存在的病毒会导致肝脏炎症、坏死，在这类刺激的反复作用下，肝星状细胞逐渐活化，再生修复受到影响，肝细胞外基质纤维化，从而导致患者发生糖尿病合并肝硬化。此类患者一旦治疗不当或治疗不及时，则会进一步造成患者病情恶化，甚至导致患者出现肝癌。在评估患者肝功能方便，前白蛋白（PA，Prealbumin）、白蛋白（ALB，Serum albumin）等是十分重要的指标，其可对患者疗效、预后予以有效评估[2]。因此本文于2017年1月--2019年10月，选取糖尿病合并肝硬化老年患者120例，回顾性分析其全部的临床资料，即探究……