蒋庆玲

[摘要] 目的 分析探究女性围绝经期功能失调性子宫出血应用米非司酮治疗的临床效果。方法 该次研究采取随机盲选法，将方便选取2018年2月—2019年4月该院收治的82例围绝经期功能失调性子宫出血患者划分为两组，每组41例;其中，对照组实行常规治疗，观察组实行米非司酮治疗，对比两组治疗效果。 结果 ①观察组治疗总有效率的95.12%，明显高于对照组的70.73%，差异有统计学意义（χ2=10.283，P<0.05）。②治疗后，对照组FSH为（9.54±2.54）U/L、LH为（7.59±1.58）U/L、E2为（124.87±65.28）nmol/L、P为（2.57±0.97）nmol/L;观察组，FSH为（8.04±1.94）U/L、LH为（6.38±1.41）U/L、E2为（105.13±59.28）nmol/L、P为（1.63±0.76）nmol/L。治疗后观察组FSH、LH、E2均明显低于对照组，P则明显高于对照组，差异有统计学意义（P<0.05）。③观察组不良反应总发生率4.88%明显低于对照组的21.95%，差异有统计学意义（χ2=11.593，P<0.05）。结论 女性围绝经期功能失调性子宫出血患者实行米非司酮治疗的效果显著，能明显提高治疗效果，降低不良反应发生率。

[关键词] 围绝经期功能失调性子宫出血;米非司酮;临床效果

[Abstract] Objective To analyze the clinical effects of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding in women. Methods The randomized convenient selection method was used in this study. The 82 patients with perimenopausal dysfunctional uterine bleeding admitted to the hospital from February 2018 to April 2019 were divided into two groups， with an average of 41 cases in each group. Among them， the control group of routine treatment was performed， and the mifepristone treatment was performed in the observation group， and the treatment effects of the two groups were compared. Results 1.The total effective rate of treatment in the observation group was 95.12%， which was significantly higher than 70.73% in the control group. The data of the two groups had statistical significance （χ2=10.283， P<0.05）. 2.After treatment， the control group FSH was （9.54±2.54）U/L， LH was （7.59±1.58）U/L， E2 was （124.87±65.28）nmol/L， and P was （2.57±0.97）nmol/L; in the observation group， FSH was （8.04±1.94）U/L， LH was （6.38±1.41）U/L， and E2 was （105.13±59.28） nmol/L. P was （1.63±0.76） nmol/L. After treatment， FSH， LH， and E2 in the observation group were significantly lower than those in the control group， and P was significantly higher than that in the control group. The data of the two groups had statistical significance（P<0.05）. 3.The total incidence of adverse reactions in the observation group was 4.88%， which was significantly lower than the control group's 21.95%. The data of the two groups had statistical significance （χ2=11.593， P<0.05）. Conclusion Mifepristone treatment in women with perimenopausal dysfunctional uterine bleeding has a significant effect， which can significantly improve the treatment effect and reduce the incidence of adverse reactions.

[Key words] Perimenopausal dysfunctional uterine bleeding; Mifepristone; Clinical effect

圍绝经期功能失调性子宫出血作为临床常见妇科疾病，指卵巢功能下降孕激素分泌锐减导致月经周期紊乱的疾病，其临床症状包括经期出血量异常及出血持续或间隔时间过长等。一旦错失最佳治疗时机则可能出现贫血症状，对女性身心健康造成极其不利的影响，反而破坏患者日常生活[1-2]。以往临床治疗围绝经期功能失调性子宫出血以性激素治疗为主要方法，治疗期间病情往往反复发作，围绝经期患者普遍无生育要求，而选择药物闭经治疗能取得令人满意的治疗效果。米非司酮是临床终止早孕的常用药物，经大量实践发现米非司酮能加快子宫内膜萎缩速度，能明显提高围绝经期失调性子宫出血的临床效果[3-4]。鉴于此，该文方便选取2018年2月—2019年4月该院收治的82例围绝经期功能失调性子宫出血患者为研究对象，重点探究女性围绝经期功能失调性子宫出血应用米非司酮治疗的临床效果，现报道如下。……