许建章 关素琴 郑津津

[摘要] 目的 研究葡萄糖酸钙锌口服溶液佐治小儿轻度腹泻的临床效果。方法 该次方便选取2017年7月—2019年7月该院收治的86例轻度腹泻患儿展开研究，按照随机数字表法分为两组，在常规治疗的基础上，对照组43例予以蒙脱石散治疗，观察组43例佐以葡萄糖酸钙锌口服溶液治疗。将两组的临床症状改善时间、血清炎性因子、临床疗效、不良反应发生情况进行比对。结果 观察组轻度腹泻患儿的发热、呕吐、腹痛腹泻等症状消失时间（22.13±3.40）h、（1.46±0.49）h、（1.40±0.32）h短于对照组，大便次数及大便性状恢复正常时间（1.10±0.21）d、（1.43±0.28）d亦短于对照组，差异有统计学意义（t=4.577、9.103、9.738、15.841、10.938，P<0.05）;观察组患者治疗后的TNF-α（2.00±0.11）pg/mL、IL-6（14.12±3.63）pg/mL均低于对照组，差异有统计学意义（t=43.898、6.450，P<0.05）;观察组患儿的临床总有效率（95.35%）高于对照组，差异有统计学意义（χ2=5.108，P<0.05）;组间对比不良反应发生情况差异无统计学意义（P>0.05）。结论 在小儿轻度腹泻治疗中辅以葡萄糖酸钙锌口服溶液安全有效，可促进患儿临床症状快速改善，降低血清炎性因子水平。

[关键词] 小儿轻度腹泻;葡萄糖酸钙锌口服溶液;效果

[Abstract] Objective To study the clinical effect of calcium and zinc gluconate oral solution in treating children with mild diarrhea. Methods This study included 86 children with mild diarrhea treated convenient celection the hospital from July 2017 to July 2019. They were divided into two groups according to the random number table method. Based on conventional treatment， 43 patients in the control group received montmorillonite in the treatment group， 43 cases were treated with calcium zinc gluconate oral solution. The clinical symptoms improvement time， serum inflammatory factors， clinical efficacy， and adverse reactions were compared between the two groups. Results The time of disappearance of fever， vomiting， abdominal pain and diarrhea in children with mild diarrhea in the observation group （22.13±3.40）d，（1.46±0.49）d， （1.40±0.32）h was shorter than that in the control group （1.10± 0.21）d， （1.43±0.28）d were also shorter than the control group， the difference was statistically significant （t=4.577， 9.103， 9.738， 15.841， 10.938， P<0.05）; TNF-α （2.00±0.11）pg/mL and IL-6 （14.12±3.63） pg/mL were lower than those in the control group， the difference was statistically significant （t=43.898， 6.450， P<0.05）; the total clinical effective rate of children in the observation group（95.35%） higher than the control group， the difference was statistically significant （χ2=5.108， P<0.05）; there was no statistically significant difference in the incidence of adverse reactions between the groups （P>0.05）. Conclusion In the treatment of children with mild diarrhea， supplemented with calcium zinc gluconate oral solution is safe and effective， which can promote the rapid improvement of clinical symptoms and reduce serum inflammatory factor levels in children.

[Key words] Mild diarrhea in children; Calcium zinc gluconate oral solution; Effect

小兒腹泻是由多病原、多因素所致的儿科疾病[1]，小儿的机体免疫能力较弱，病毒、细菌、寄生虫及真菌等病原微生物容易侵入患儿机体，加上肠道外感染、抗菌药物滥用等因素，会导致肠道菌群紊乱[2]，促使肠道细胞壁离子通道通透性得到改善[3]。儿童的生长发育速度较快，对营养需求比较旺盛，腹泻会引起水电解质紊乱、脱水，严重者甚至可能出现死亡，因此在临床治疗中应注意及时对腹泻患儿进行有效的治疗。该文对葡萄糖酸钙锌口服溶液在小儿轻度腹泻中的效果进行探讨，特方便择取2017年7月—2019年7月期间收治的86例轻度腹泻患儿进行对照研究，现报道如下。……