黄懿文

[摘要] 目的 研究糖尿病肾病与脂代谢异常之间的关系。方法 研究时段是在2018年1月—2019年11月选择该院接收的100例单纯糖尿病患者为甲组，选择该院接收的80例糖尿病肾病患者为乙组，另择取70例同期健康体检者为对照组，均检测研究对象的临床生化指标，比较3组的检查结果。结果 乙组患者总胆固醇（5.69±1.42）mmol/L、甘油三酯（2.70±1.18）mmol/L、低密度脂蛋白（3.59±1.12）mmol/L及载脂蛋白A（320.87±99.12）mmol/L指标明显高于甲组、对照组;乙组患者高密度脂蛋白（0.95±0.22）mmol/L、对氧磷脂酶-1指标（103.45±36.87）ku/L低于甲组、对照组，差异有统计学意义（P<0.05）。结论 脂代谢异常对糖尿病肾病造成不同程度的加重，因此治疗疾病时高度重视脂代谢很重要，便于控制疾病進展且获得良好的效果。

[关键词] 糖尿病肾病;脂代谢异常;相关性

[中图分类号] R58          [文献标识码] A          [文章编号] 1672-4062（2020）03（b）-0195-02

[Abstract] Objective To study the relationship between diabetic nephropathy and abnormal lipid metabolism. Methods The study period was from 2018.1-2019.11. 100 patients with simple diabetes received by our hospital were selected as group A， 80 patients with diabetic nephropathy received by our hospital were selected as group B， and 70 patients with healthy physical examination during the same period were selected as the control group. The clinical biochemical indicators of the study subjects were detected， and the test results of the three groups were compared. Results Total cholesterol （5.69±1.42）mmol/L， triglycerides （2.70±1.18）mmol/L， low density lipoprotein （3.59±1.12）mmol/L， and apolipoprotein A （320.87±99.12）mmol in group B （L） index was significantly higher than those in group A and control group; the high-density lipoprotein （0.95±0.22）mmol/L and paraoxidase-1 index （103.45±36.87）ku/L in group B were lower than those in group A and control group， P<0.05 （statistically significant）. Conclusion Abnormal lipid metabolism can cause diabetic nephropathy to different degrees. Therefore， it is important to pay great attention to lipid metabolism in the treatment of diseases， which is convenient for controlling disease progression and obtaining good results.

[Key words] Diabetic nephropathy; Abnormal lipid metabolism; Correlation

部分研究结果表明，糖尿病患者最重要的合并症之一是糖尿病肾病，具有发病率高、病程长及迁延难愈等特点，与遗传、肾脏血流动力学异常、高血压及高血糖等因素有关，患病后有蛋白尿、慢性高血糖等表现，未接受及时治疗可能引起肾衰竭危及生命。部分研究结果表明，糖尿病患者常见并发症是脂代谢紊乱，与微血管病变、大血管并发症有关，其中载脂蛋白A与低密度脂蛋白对糖尿病肾病发生发挥着至关重要的作用，并且部分学者证实，氧磷脂酶参与低密度脂蛋白的代谢，预防机体内堆积氧化低密度脂蛋白，缓解微血管损害，因此早期分析脂代谢异常、糖尿病肾病直接的相关性，便于提出对症治疗改善患者预后效果[1]。2018年1月2019年11月该研究分析糖尿病肾病与脂代谢异常之间的关系，报道如下。

1  资料与方法

1.1  一般资料……