[摘要] 目的 研究血清C肽与糖化血红蛋白联合检验诊断糖尿病的临床应用效果。方法 方便选取2016年1月—2019年1月期间该院收治的50例糖尿病患者纳入观察组，对照组选取同期糖化血红蛋白与C肽正常的住院患者50例，检测两组受检者的血糖水平、血清C肽、糖化血红蛋白水平并进行比较，分析后血清C肽、糖化血红蛋白水平两项指标与糖尿病的相关性。结果 观察组糖尿病患者的空腹血糖（9.58±2.13）mmol/L、餐后2 h血糖（12.49±2.42）mmol/L、糖化血紅蛋白水平（10.66±2.53）%均高于对照组，血清C肽水平（0.88±0.06）ng/mL低于对照组，差异有统计学意义（t=16.130、20.005、15.276、6.345， P<0.05）;观察组中，血清C肽水平、糖化血红蛋白水平分别与糖尿病病情严重程度呈负相关、正相关，差异有统计学意义（r=-0.723、0.571，P<0.05）。结论 血清C肽联合糖化血红蛋白应用于糖尿病诊断中的效果确切，可为临床诊断糖尿病、评估疗效提供有价值的参考，可作为糖尿病的常规诊断措施，适合推广应用在临床中。

[关键词] 糖尿病;血清C肽;糖化血红蛋白;空腹血糖、餐后2 h血糖;诊断

[中图分类号] R5          [文献标识码] A          [文章编号] 1674-0742（2020）02（b）-0186-03

Clinical Application Analysis of Combined Detection of Serum C-peptide and Glycosylated Hemoglobin for Diagnosis of Diabetes

Yin Ji-mei

Department of Clinical Laboratory， People's Hospital of Pizhou， Pizhou， Jiangsu Province， 221300， China

[Abstract] Objective To study the clinical application of serum C-peptide and glycosylated hemoglobin in the diagnosis of diabetes. Methods Fifty patients with diabetes admitted to the hospital from January 2016 to January 2019 were convenienty enrolled in the observation group. The control group selected 50 patients with normal glycosylated hemoglobin and C-peptide in the same period. The blood glucose levels of the two groups were tested. The levels of serum C-peptide and glycated hemoglobin were comparedand analyzed. The correlation between serum C-peptide and glycated hemoglobin levels and diabetes was analyzed. Results The fasting blood glucose （9.58±2.13）mmol/L， postprandial 2 h blood glucose （12.49±2.42）mmol/L， and glycosylated hemoglobin level （10.66±2.53）% were higher in the observation group than in the control group，serum C-peptide level（0.88±0.06）ng/mL was lower than the control group， the difference was statistically significant （t=16.130， 20.005， 15.276， 6.345， P<0.05）; In the observation group， serum C-peptide level， glycated hemoglobin level and diabetes， respectively. The severity of the disease was negatively correlated and positively correlated， and the difference was statistically significant （r=-0.723， 0.571， P<0.05）. Conclusion Serum C-peptide combined with glycosylated hemoglobin has a definiteeffect in the diagnosis of diabetes. It can provide a valuable reference for clinical diagnosis of diabetes and evaluate the efficacy. It can be used as a routine diagnostic measure for diabetes and suitable for clinical application.

[Key words] Diabetes; Serum C-peptide; Glycated hemoglobin; Fasting blood glucose， 2 h postprandial blood glucose; Diagnosis

糖尿病是一种慢性代谢性疾病[1]，该病的发生与患者机体胰岛素分泌缺陷、胰岛素抵抗有关，高血糖为糖尿病的主要特征，长期的高血糖状态会损害患者的心、肾脏、眼部等多个系统和器官[2]，导致糖尿病相关并发症的发生，增加临床治疗难度，严重影响患者的身心健康和生存质量，尽早诊断糖尿病便于实施相应的降糖措施，避免病情持续进展。以往糖尿病诊断中的主要指标为空腹血糖、餐后2 h血糖、糖耐量，受患者自身或其他因素的影响，诊断效果有一定局限性存在，容易出现误诊、漏诊情况，因此需选择更加准确、有效的检测指标和方法。该文对血清C肽与糖化血红蛋白联合检验的效果进行分析，以促进糖尿病临床诊断准确性的提高，故此特择取2016年1月—2019年1月期间该院收治的糖尿病患者50例和糖化血红蛋白与C肽正常的住院患者50例作为研究对象。……