靳银欣 曾慧 杨慧娟

【摘  要】目的：定量评价老年2型糖尿病患者认知干预的效果。方法：计算机检索中国生物医学文献数据库、中国知网、维普期刊、万方数据库、Pubmed、MEDLINE、Cochrane Library等数据库，采用不同的检索方式对公开发表的中英文文献数据进行检索，对检索结果进行严格筛选，最后选出符合要求的文献，由2名评价者独立对文献进行质量评价和数据收集。并用Cochrane协作网提供的RevMan 5.3统计软件对提取的计量资料进行Meta分析。结果：初检出294篇文獻，经筛选最终纳入14篇进行Meta分析。结果显示，试验组血糖、糖化血红蛋白在干预后第3、6、12、18个月时均显著降低，认知功能评分显著提高，与对照组比较，差异有统计学意义，试验组优于对照组。结论：认知干预在短期内（3-18个月）可以改善老年2型糖尿病患者的血糖、糖化血红蛋白和认知功能。

【关键词】糖尿病;认知功能;认知干预;Meta分析

【中图分类号】R587      【文献标识码】A      【文章编号】1672-3783（2019）01-0264-02

【Abstract】Objective：To quantitatively evaluate the effect of cognitive intervention in elderly patients with type 2 diabetes. Methods：The computer searched the Chinese biomedical literature database， China Knowledge Network， Weipu Journal， Wanfang Database， Pubmed， MEDLINE， Cochrane Library and other databases， using different search methods to search the published Chinese and English literature data， and strictly enforce the search results. Screening， and finally select the documents that meet the requirements， and the two evaluators independently conduct quality evaluation and data collection on the literature. Meta-analysis of the extracted measurement data was performed using the RevMan 5.3 statistical software provided by the Cochrane Collaboration. Results：A total of 294 articles were detected， and 14 were selected for meta-analysis. The results showed that the blood glucose and glycated hemoglobin in the experimental group were significantly decreased at the 3rd， 6th， 12th and 18th months after the intervention， and the cognitive function score was significantly increased. Compared with the control group， the difference was statistically significant. The experimental group was superior to the control group. group. Conclusion：Cognitive intervention can improve blood sugar， Glycated hemoglobin and cognitive function in elderly patients with type 2 diabetes in a short period of time （3-18 months）.

【Keywords】diabetes; cognitive function; cognitive intervention; meta-analysis

随着人口老龄化的加剧，2型糖尿病和痴呆已经成为全球面临的社会问题和公共卫生问题。2017年IDF全球糖尿病概览第8版据估计全球约4.25亿人患有糖尿病[1]，可以说8.8% 的20-79 岁成人患有糖尿病。如果年龄扩大到 18-99岁，则糖尿病患者数量会增加到4.51亿。如果按照这类趋势持续下去，那么预计到 2045年，将会有6.93亿的18-99岁人群，即6.29亿的20-79岁人群患有糖尿病。按年龄分布，处于工作年龄（20-64岁）的糖尿病患者有3.265 亿，65-99岁的糖尿病患者有1.228亿，可见老年糖尿病患者占很大比例。到2045 年，处于工作年龄的糖尿病患者人数预计将增加到4.382亿，65-99岁的糖尿病患者人数将增加到2.534亿。……