唐崇瑜

[摘要]目的 探讨羟苯磺酸钙联合益肾化湿颗粒治疗慢性肾炎患者的临床效果。方法 选取2016年1月～2017年12月我院收治的60例慢性肾炎患者作为研究对象，按照随机数字表法分为对照组和观察组，每组各30例。对照组采取常规综合治疗，观察组在对照组的基础上加用益肾化湿颗粒和羟苯磺酸钙，记录并对比两组患者的24 h尿蛋白定量和临床治疗效果。结果 治疗后，观察组患者24 h尿蛋白定量、血肌酐和血尿素氮低于对照组，而血清清蛋白高于对照组（P<0.05）;观察组患者的临床总有效率高于对照组（P<0.05）。结论 羟苯磺酸钙联合益肾化湿颗粒治疗慢性肾炎患者，可有效降低患者的24 h尿蛋白定量，减少蛋白尿的排泄，有效改善患者的临床治疗效果。

[关键词]慢性肾炎蛋白尿;益肾化湿颗粒;羟苯磺酸钙;临床疗效

[中图分类号] R692.31          [文献标识码] A          [文章编号] 1674-4721（2019）6（a）-0098-03

[Abstract] Objective To investigate the clinical effect of Calcium Hydroxybenzenesulfonate combined with Yishen Huashi Granules in the treatment of patients with chronic nephritis. Methods A total of 60 patients with chronic nephritis proteinuria treated in our hospital from January 2015 to December 2017 were selected as the subjects. The patients were divided into control group and observation group according to random number table method， with 30 cases in each group. The control group received routine comprehensive treatment. The observation group was supplemented with Yishen Huashi and Calcium Hydroxybenzenesulfonate on the basis of the control group. The 24-hour urine protein quantitation and clinical treatment effects of the two groups were recorded and compared. Results After treatment， the 24-hour urine protein quantitation， serum creatinine and blood urea nitrogen in the observation group were lower than those in the control group， and serum albumin was higher than that in the control group （P<0.05）. The total clinical effective rate of the observation group was higher than that of the control group （P<0.05）. Conclusion Yishen Huashi combined with Calcium Hydroxybenzenesulfonate in the treatment of chronic nephritis proteinuria patients can effectively reduce the 24-hour urine protein quantitation， reduce proteinuria excretion， and effectively improve the clinical treatment effect of patients.

[Key words] Chronic nephritis proteinuria; Yishen Huashi Granules; Calcium Hydroxybenzenesulfonate; Clinical efficacy

慢性腎小球肾炎，又称为慢性肾炎，是临床上常见的多发病和常见病，也是导致慢性肾衰竭的首要疾病[1]。在临床中，持续的尿蛋白有可能会导致患者出现肾小球基底膜增厚的现象，或者系膜基质增加，从而导致患者出现肾小球硬化现象[2]。目前，慢性肾小球肾炎的主要治疗目的为防止或延缓肾功能恶化、防治严重合并症，常采用综合治疗措施进行治疗，可采用的药物包括有糖皮质激素、细胞毒药物、抗凝药物、纤溶药物或者抗血小板解聚药物等，不过在使用药物治疗的同时要依据患者的身体实际情况[3]。本研究选取我院收治的60例慢性肾炎患者作为研究对象，旨在探讨羟苯磺酸钙联合益肾化湿颗粒治疗慢性肾炎患者的临床效果，现报道如下。

1资料与方法

1.1一般资料

选取2016年1月～2017年12月我院收治的60例慢性肾炎患者作为研究对象，按照随机数字表法分为对照组和观察组，每组各30例。……