刘喆

【摘要】 目的：回顾性分析对小儿手足口病患儿在常规治疗的基础上采取开喉剑喷雾剂联合炎琥宁治疗的临床效果。方法：选取笔者所在医院2017年5月-2018年10月收治的98例小儿手足口病患儿，根据治疗方法不同将其分为治疗组和对照组，各49例，均先进行常规治疗，对照组联合热毒宁治疗，治疗组采用开喉剑喷雾剂联合炎琥宁治疗，比较两组患儿症状缓解时间、治疗效果及不良反应。结果：治疗组治疗总有效率为95.92%，显著高于对照组的71.43%，差异有统计学意义（P<0.05）。治疗组皮疹消退时间（3.25±1.22）d，退热时间（1.43±0.32）d，口腔疱疹好转时间（3.78±1.02）d，口腔溃疡好转时间（2.39±0.53）d，均显著优于对照组，差异有统计学意义（P<0.05）。治疗组不良反应发生率为12.24%，显著低于对照组的40.82%，差异有统计学意义（P<0.05）。结论：对小儿手足口病患儿在常规治疗的基础上采取开喉剑喷雾剂联合炎琥宁治疗的临床效果显著，症状缓解快，安全性好，值得临床推广。

【關键词】 小儿手足口病; 药物治疗; 临床效果

doi：10.14033/j.cnki.cfmr.2019.27.019 文献标识码 B 文章编号 1674-6805（2019）27-00-03

Retrospective Study on Clinical Treatment of Hand，Foot and Mouth Disease in Children/LIU Zhe.//Chinese and Foreign Medical Research，2019，17（27）：43-45

【Abstract】 Objective：To retrospectively analyze the clinical effect of Kaihoujian Spray combined with Yanhuning on the treatment of children with hand，foot and mouth disease on the basis of routine treatment.Method：A total of 98 children with hand，foot and mouth disease admitted in our hospital from May 2017 to October 2018 were selected and divided into treatment group and control group according to different treatment methods，49 cases in each group.All patients were treated with conventional therapy.The control group combined with Reduning treatment，the treatment group was treated with Kaihoujian Spray combined with Yanhuning treatment.The symptom relief time，treatment effect and adverse reactions were compared between the two groups.Result：The total effective rate of the treatment group was 95.92%，which was significantly higher than 71.43% of the control group，the difference was statistically significant（P<0.05）.The rash regression time（3.25±1.22），the antipyretic time（1.43±0.32）d and the oral herpes improvement time（3.78±1.02）d，oral ulcers improvement time（2.39±0.53）d，which were significantly better than those in the control group，the differences were statistically significant（P<0.05）.the incidence of adverse reactions in the treatment group was 12.24% significantly lower than 40.82% in the control group，the difference was statistically significant（P<0.05）.Conclusion：On the basis of conventional treatment，Kaihoujian Spray combined with Yanhuning for the treatment of children with hand，foot and mouth disease has obvious clinical effect，rapid relief of symptoms and good safety，which is worthy of clinical promotion.

【Key words】 Hand，foot and mouth disease; Drug therapy; Clinical effect

First-authors address：Changzhou Childrens Hospital，Changzhou 213000，China

小儿手足口病在临床上十分普遍，多因肠道病毒感染导致，5岁以内的小儿患病率最高，由于病毒能够在患儿的咽部和唾液寄生，因此，能够在玩耍期间通过打喷嚏、咳嗽等途径传染给其他小儿，同时，患儿的玩具、餐具等均能够通过病毒机械能传播，最终在一定范围内形成流行趋势，出现多个小儿患病的情况[1-2]。小儿一旦发病，就会在手足部、口腔及臀部等皮肤部位出现斑丘疹或者疱疹，且伴有不同程度的发热，出现哭闹，厌食等情况[3]。临床治疗主要以药物治疗，且临床上药物种类繁多，效果不一[4]，为进一步探讨对小儿手足口病患儿在常规治疗的基础上采取开喉剑喷雾剂联合炎琥宁治疗的临床效果，本文将笔者所在医院2017年5月-2018年10月收治的98例小儿手足口病患儿作为研究对象，现报道如下。

1 资料与方法

1.1 一般资料

选取笔者……