杨玉华

[摘要] 目的 研究硫酸镁与硝苯地平联合疗法在妊高症中的应用价值。 方法 選择2016年2月～2018年1月本科接诊的妊高症患者76例，按照电脑随机双盲法进行分组：试验组（n=38）实行硫酸镁联合硝苯地平治疗，对照组（n=38）单用硫酸镁。分析两组用药后舒张压与收缩压的变化情况，比较不良反应发生率等指标。 结果 试验组的治疗总有效率为94.74%，明显比对照组的78.95%高，组间差异显著（P<0.05）。试验组治疗后的收缩压与舒张压水平明显比对照组低，组间差异显著（P<0.05）。试验组的不良反应发生率为5.26%，明显比对照组的18.42%低，组间差异显著（P<0.05）。 结论 积极对妊高症患者施以硫酸镁与硝苯地平联合治疗，可显著提升其整体疗效，促进血压水平降低，减少不良反应发生风险，促进病情早日康复，建议推广和使用。

[关键词] 硝苯地平；妊高症；硫酸镁；血压水平

[中图分类号] R714.252 [文献标识码] B [文章编号] 1673-9701（2018）25-0065-03

[Abstract] Objective To study the application value of combined therapy of magnesium sulfate and nifedipine in pregnancy-induced hypertension. Methods A total of 76 patients with pregnancy-induced hypertension who were admitted to our department from February 2016 to January 2018 were selected. In accordance with the computer random double-blinded method， the patients were assigned to groups： The experimental group（n=38） was given magnesium sulfate combined with nifedipine. The control group（n=38） was given magnesium sulfate alone. The changes in diastolic blood pressure and systolic blood pressure after drug administration in the two groups were analyzed. The indicators such as the the incidence rate of adverse reactions were compared. Results The total effective rate in the experimental group was 94.74%， which was significantly higher than that of 78.95% in the control group. There was a significant difference between the groups（P<0.05）. The systolic blood pressure and diastolic blood pressure in the experimental group were significantly lower than those in the control group after treatment， and there was a significant difference between the groups（P<0.05）. The incidence rate of adverse reactions in the experimental group was 5.26%， which was significantly lower than that of 18.42% in the control group. The difference between the groups was significant（P<0.05）. Conclusion The combination of magnesium sulphate and nifedipine in the treatment of patients with pregnancy-induced hypertension can significantly improve its overall efficacy， reduce blood pressure level， reduce the risk of adverse reactions， and promote the recovery of the disease soon. It is recommended to promote and use.

[Key words] Nifedipine；Pregnancy-induced hypertension；Magnesium sulfate；Blood pressure level

临床上，妊高症，即妊娠高血压，具有较高的发病率，主要包含子痫前期、妊娠期高血压、慢性高血压、子痫及慢性高血压并发子痫前期等病理类型，乃妊娠期孕妇比较特殊的一种疾病[1]。据有关调查数据显示，我国现阶段中的妊娠高血压发病率在9.4%左右，而外国的发病率则在7%～12%[2]。因妊高症能够对孕妇及胎儿的生命健康造成较大损伤，且其同时也是孕产妇与围生儿死亡的一个重要因素[3]，所以，临床必须要加强对本病患者进行早期对症治疗的力度。硫酸镁在妊高症中的使用比较广泛，可抑制患者病情进展，但单一用药并不能取得较显著的成效。对此，本文将重点分析妊高症患者联用硫酸镁与硝苯地平的临床疗效及安全性，现报道如下。

1 资料与方法

1.1 一般资料

選择2016年2月～2018年1月间本科收治的76例妊高症产妇。按照电脑随机双盲法对所选病例进行分组：试验组和对照组，各38例。试验组的年龄25～38岁，平均（32.67±4.15）岁；孕周38～41周，平均（39.26±0.73）周；……