尹慧 熊静芳 金贝贝

[摘要] 目的 探讨胰岛素泵与多次胰岛素皮下注射治疗初诊2型糖尿病的临床疗效。 方法 选取2015年1月～2017年1月我院住院治疗的2型糖尿病患者80例，随机分为对照组与观察组，各40例。观察组采用胰岛素泵持续输注，对照组予多次胰岛素强化治疗，两组均治疗2周。治疗后比较两组临床疗效及血糖各项指标的变化情况、胰岛素用量和低血糖的发生率。 结果 观察组患者治疗后的总有效率达97.5%，明显高于对照组的77.5%，组间比较差异具有统计学意义（P<0.05）。观察组患者治疗后的胰岛素用量少于对照组，血糖达标时间短于对照组，组间比较差异具有统计学意义（P<0.05）。观察组患者治疗后的各项血糖指标均低于对照组，组间比较差异具有统计学意义（P<0.05）。 结论 胰岛素泵治疗初诊2型糖尿病的疗效明显优于多次胰岛素皮下注射的方式，可以有效控制血糖且减少胰岛素用量及降低低血糖的发生率，值得广泛推广和应用。

[关键词] 初诊2型糖尿病；胰岛素泵；多次胰岛素；低血糖

[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701（2018）25-0101-04

[Abstract] Objective To analyze the clinical efficacy of insulin pump and multiple insulin subcutaneous injections for newly diagnosed type 2 diabetes. Methods Eighty patients with type 2 diabetes hospitalized in our hospital from January 2015 to January 2017 were randomly divided into control group and observation group， with 40 cases in each group. The observation group used insulin pump continuous infusion， and the control group received multiple insulin intensive treatment. Both groups were treated for 2 weeks. After treatment， the clinical efficacy， changes in blood glucose levels， insulin intake， and incidence rate of hypoglycemia were compared. Results The total effective rate of the observation group after treatment was 97.5%， which was significantly higher than that of the control group 77.5%. The difference between the groups was statistically significant（P<0.05）. The doses of insulin after treatment in the observation group was lower than that in the control group， and the time for blood glucose reaching the target was shorter than that in the control group. The difference between the groups was statistically significant（P<0.05）. The blood glucose levels in the observation group were lower than those in the control group after treatment. The difference between the two groups is statistically significant（P<0.05）. Conclusion The effect of insulin pump treatment on newly diagnosed type 2 diabetes was obviously better than that of multiple insulin subcutaneous injections， which can effectively control blood glucose， reduce insulin dosage and reduce the incidence of hypoglycemia， and thus is worthy of extensive promotion and application.

[key words] Newly diagnosed type 2 diabetes； Insulin pump； Multiple insulin； Hypoglycemia

近年来，随着人们生活水平的提高及现代社会生活節奏的加快，饮食结构的不合理和肥胖以及人口老龄化，糖尿病的的发病率和患病率逐年增加[1]。糖尿病是一种严重的慢性病，由于血糖升高可引起人体各种组织，特别是眼睛、肾脏、心脏、血管、神经的慢性损害、功能障碍或衰竭[2]。所以合理选择胰岛素并适时开始强化降糖治疗可以降低微血管病变的发生率，还有可能带来长期的心血管获益，有效阻止或延缓并发症的发生[3]。胰岛素是治疗糖尿病最有效的药物之一，可有效控制高血糖，最大程度地解除糖毒性的影响[4]。2型糖尿病患者应尽早使用胰岛素，才能促进胰岛β细胞功能的恢复，延缓慢性并发症的发生和发展[5]。胰岛素强化治疗有两种方式，分别是连续皮下泵入和多次皮下注射[6]，本研究旨在探讨胰岛素泵与多次胰岛素皮下注射治疗糖尿病的效果，现报道如下。……