郭婷　何虹　胡丰阳　梅孟雪　刘佩蓉

[摘要] 目的 探讨复方黄柏液治疗卡培他滨所致手足综合征的效果。 方法 选取2017年1月～2018年3月南昌大学第二附属医院肿瘤科80例手足综合征患者为研究对象，采用随机数字表法将其分为试验组与对照组，每组各40例。试验组采用复方黄柏液湿敷，对照组给予自配液湿敷，每天湿敷前，先使用生理盐水清洗伤口，再用无菌纱块浸渍后进行湿敷，30 min后取下纱块，3次/d。治疗1周后，观察患者手足综合征分级变化、治疗效果、症状改善情况，利用皮肤敏感值-16（Skindex-16）量表对患者的生活质量进行评估。 结果 干预后，试验组手足综合征分级变化明显优于对照组，总有效率显著高于对照组，Skindex-16得分、症状评分均显著低于对照组，差异均有统计学意义（P < 0.05）。 结论 复方黄柏液湿敷治疗卡培他滨所致手足综合征效果较好，能有效改善患者症状，提高患者生活质量。

[关键词] 复方黄柏液；卡培他滨；手足综合征

[中图分类号] R248 [文献标识码] A [文章编号] 1673-7210（2018）09（b）-0125-04

[Abstract] Objective To explore the therapeutic effect of Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome. Methods Eighty cases of patients with hand-foot syndrome in the Department of Oncology of a triple-A general hospital in Nanchang City from January 2017 to March 2018 were selected as research objects， and they were divided into the experimental group and the control group by random number table method， with 40 cases in each group. The experimental group was given hydropathic compress with Compound Cortex Phellodendri Liquid， and the control group was was given hydropathic compress with self-made liquid. Before hydropathic compress， the wound was cleaned with normal saline， and then the hydropathic compress was applied after the impregnation of aseptic gauze block. After 30 minutes， the gauze block was removed， 3 times a day. After 1 week of treatment， the changes of hand-foot syndrome grade， the therapeutic effect and the improvement of symptoms were observed. The quality of life was evaluated by Skindex-16 scale. Results After intervention， the changes of hand-foot syndrome grade in the experimental group were better than those of control group， the total effective rate was higher than that of control group， and the scores of Skindex-16 and symptoms were all lower than those of control group， the differences were all statistically significant （P < 0.05）. Conclusion Hydropathic compress with Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome has good effects， which can effectively improve the symptoms and the quality of life of the patients.

[Key words] Compound Cortex Phellodendri Liquid； Capecitabine； Hand-foot syndrome

手足综合征是某些抗肿瘤药物引起的剂量依赖性皮肤毒性反应，发病机制尚不明确，其中卡培他滨引起的发生率较高，达到53.5%～60.0%[1-3]。西医治疗方式较为局限，缺乏有效的预防措施和对症处理药物，主要通过调整药物剂量、必要时给予暂时性的治疗中断来达到改善症状的目的[4]。许多学者在中医辨证论治的指导下将手足综合征归为“痹证”的范畴，病因病机为癌毒之邪入侵致瘀血凝滞、湿热郁结、络脉瘀阻，治疗当祛湿活血通络[5-6]。而复方黄柏液具有燥湿收敛、杀菌止痒、消瘀通脉的功效，对湿热毒邪蕴结的皮肤疾患具有独特功效[7]。……