不同种类CA125浓度测量值对子宫内膜异位症与子宫腺肌症的鉴别诊断价值
2018-11-28方淑芬万玉珍
方淑芬 万玉珍
[摘要] 目的 探讨不同种类CA125浓度测量值对子宫内膜异位症与子宫腺肌症的鉴别诊断价值。 方法 选择2015年1月~2017年12月在江西省妇幼保健院进行治疗的子宫内膜异位症患者30例(B组)、子宫腺肌症患者30例(C组)和健康体检者30例(A组)资料进行对比,分析血清与腹腔液中CA125的浓度及对疾病的诊断价值。结果 三组患者的血清CA125、腹腔液CA125浓度、AFS评分比较,差异均具有统计学意义(F=746.099、331.191、75.394,P<0.05),B组患者的腹腔液CA125阳性率(73.33%)高于血清CA125阳性率(43.33%),C组患者的血清CA125阳性率(83.33%)高于腹腔液CA125阳性率(13.33%),差异均具有统计学意义(χ2=5.554, 29.433,P<0.05),子宫内膜异位症患者AFS评分结果与血清CA125和腹腔液CA125浓度值之间均呈正相关(r=0.536、0.737,P<0.05)。 结论 血清和腹腔液CA125的浓度对于子宫内膜异位症与子宫腺肌症的诊断灵敏度不同,需要根据患者的情况进行综合考虑,使用CA125的浓度值对病情推断具有较高的价值。
[关键词] 子宫内膜异位症;子宫腺肌症;腹腔液;癌抗原125
[中图分类号] R711.71 [文献标识码] B [文章编号] 1673-9701(2018)21-0059-05
[Abstract] Objective To investigate the value of differential diagnosis of different CA125 concentration measurements for endometriosis and adenomyosis. Methods The data of 30 patients with endometriosis(group B), 30 patients with adenomyosis(group C) and 30 healthy subjects(group A) who were treated in Jiangxi Women and Childrens Hospital from January 2015 to December 2017 were selected and compared. The concentration of CA125 in serum and peritoneal fluid and its diagnostic value for disease were analyzed. Results There were statistically significant differences in serum CA125, peritoneal fluid CA125 and AFS scores between the three groups(F=746.099, 331.191, 75.394, P<0.05). The positive rate of CA125 in peritoneal fluid in group B(73.33%) was higher than that of serum CA125(43.33%). The positive rate of serum CA125 in group C(83.33%) was higher than that of peritoneal fluid CA125(13.33%). The data differences were statistically significant(χ2=5.554, 29.433, P<0.05). The AFS scores in the patients with endometriosis were positively correlated with serum CA125 and peritoneal fluid CA125 concentrations(r=0.536, 0.737, P<0.05). Conclusion Serum and peritoneal fluid CA125 concentrations have a consistent diagnosis sensitivity for endometriosis and adenomyosis, which need to consider comprehensively according to the patient's conditions. The use of CA125 concentration values has a higher value for the prediction of disease conditions.
[Key words] Endometriosis; Adenomyosis; Peritoneal fluid; CA125
子宮内膜组织出现在人体内子宫之外的任意部分均被称之为异位的子宫内膜,从临床工作角度看,出现异位的子宫内膜可以导致子宫内膜异位症与子宫腺肌症[1]。子宫内膜异位症[2]的定义是具有活性的内膜细胞种植在子宫内膜以外的位置而形成的常见妇科疾病。内膜细胞本该生长在子宫腔内,但由于子宫腔通过输卵管与盆腔相通,因此使得内膜细胞可经由输卵管进入盆腔异位生长。子宫腺肌症[3]是指子宫内膜腺体和间质侵入子宫肌层形成弥漫或局限性的病变,与子宫内膜异位症一样,属于妇科常见病和疑难病。目前研究结果尚无法给出两种疾病的确切病因,而且两种疾病的发生发展过程、临床表现与疾病的预后有着较大的差别,但是在疾病的早期存在着一定的鉴别诊断困难。因此长久以来,研究者们都在试图寻找对于两种疾病进行诊断的方法。随着医学科……
