高敏肌钙蛋白T和肌红蛋白联合检测在急性心肌梗死早期诊断中的应用及其临床价值
2018-11-13韦小荣黄丽秀刘晓艳
韦小荣 黄丽秀 刘晓艳
[摘要] 目的 探討高敏肌钙蛋白T和肌红蛋白联合检测在急性心肌梗死早期诊断中的应用及其临床价值。 方法 选取2017年1~12月我院收治的急性心肌梗死93例为研究组,选取93例健康者为对照组,在研究组患者发病后的4 h及12 h时,检测其血液中的高敏肌钙蛋白T和肌红蛋白含量,与对照组的检测含量作对比。结果 研究组患者高敏肌钙蛋白和肌红蛋白含量明显高于对照组(P<0.05);研究组患者发病后0~12 h高敏肌钙蛋白呈现上升趋势(P<0.05)。 结论 本研究结果提示高敏肌钙蛋白T和肌红蛋白联合检测急性心肌梗死能提高准确性,临床上应当进一步推广应用。
[关键词] 高敏肌钙蛋白T;肌红蛋白;急性心肌梗死;早期诊断
[中图分类号] R542.22 [文献标识码] B [文章编号] 1673-9701(2018)20-0135-03
Application and its clinical value of combined detection of high-sensitivity troponin T and myoglobin in the early diagnosis of acute myocardial infarction
WEI Xiaorong HUANG Lixiu LIU Xiaoyan
Clinical Laboratory, Wuming Hospital of Guangxi Medical University, Nanning 530199, China
[Abstract] Objective To investigate the application and clinical value of combined detection of high-sensitivity troponin T and myoglobin in the early diagnosis of acute myocardial infarction. Methods 93 cases of acute myocardial infarction who were admitted to our hospital from January to December 2017 were selected as the study group. 93 healthy subjects were selected as the control group. At 4h and 12 h after onset in the study group, the high-sensitivity troponin T and myoglobin levels in their blood were detected, which were compared with the levels in the control group. Results The levels of high-sensitivity troponin T and myoglobin in the study group were significantly higher than those in the control group(P<0.05); the level of high-sensitivity troponin T in the study group showed a rising trend within 0~12 h(P<0.05). Conclusion The results of this study suggest that high-sensitivity troponin T combined with myoglobin in the detection of myocardial infarction can improve accuracy, which should be further promoted and applied in clinical practice.
[Key words] High-sensitivity troponin T; Myoglobin; Acute myocardial infarction; Early diagnosis
急性心肌梗死(acute myocardial infarction,AMI)主要病症表现为循环功能障碍、心肌坏死、胸痛、心肌损伤以及缺血等,主要是由患者体内心肌长时间的严重缺血导致了急性心肌坏死[1]。在临床的早期对肌酸激酶同工酶的酶活力进行检测,目前主要是对患者体内的蛋白质的含量进行检测,如肌钙蛋白、肌酸激酶同工酶质量等[2-3]。现在出现高敏肌钙蛋白后被应用在临床上,对心肌损伤诊断的特异性及完整性越来越完善。在本文中,通过对急性心肌梗死患者体内的肌红蛋白(Myo)、传统肌钙蛋白T(cTnT)以及高敏肌钙蛋白T(hs-cTnT)含量的变化,分析高敏肌钙蛋白T和肌红蛋白联合检测在急性心肌梗死早期诊断中的应用及其临床价值,现报道如下。
1 资料与方法
1.1一般资料
选取2017年1~12月我院收治的急性心肌梗死且发病在3 h之内的患者93例,作为研究组,其中男50例,女43例,年龄30~72岁,平均(55.8±6.7)岁。入选标准为:(1)符合世界卫生组织制定的急性心肌梗死诊断的标准;……
