詹勤元　蔡云　陈颖兰

[摘要]目的 探討培美曲塞联合参芪扶正注射液一线治疗老年晚期肺腺癌的临床效果。方法 选取2016年2月～2017年10月我院收治的80例老年晚期肺腺癌患者作为研究对象，采用随机数字表法将其分为对照组和观察组，每组各40例。对照组患者单独使用培美曲塞治疗，观察组患者在对照组化疗基础上联合参芪扶正注射液治疗。比较两组患者的治疗总有效率、肿瘤控制率、不良反应发生率及治疗前后的睡眠质量评分、生活质量评分。结果 两组患者的治疗总有效率、肿瘤控制率比较，差异无统计学意义（P>0.05）。观察组患者的不良反应发生率（2.50%）低于对照组（27.50%），差异有统计学意义（P<0.05）。治疗前，两组患者的睡眠质量评分、生活质量评分比较，差异无统计学意义（P>0.05）。治疗后，观察组患者的睡眠质量评分低于对照组，生活质量评分高于对照组，差异有统计学意义（P<0.05）。结论 在老年晚期肺腺癌的化疗中，采用培美曲塞或联合参芪扶正注射液治疗均具有一定效果，但联合治疗可有效减少不良反应的发生率，改善患者预后状态的效果显著，具有较高的临床推广价值。

[关键词]培美曲塞；参芪扶正注射液；老年；晚期肺腺癌；睡眠质量评分；生活质量评分

[中图分类号] R734.2 [文献标识码] A [文章编号] 1674-4721（2018）7（b）-0131-03

[Abstract] Objective To explore the clinical effect of Pemetrexed combined with Shenqi Fuzheng Injection as first line treatment in elderly patients with advanced lung adenocarcinoma. Methods A total of 80 cases of elderly patients with advanced lung adenocarcinoma treated in our hospital from February 2016 to October 2017 were selected as subjects. They were randomly divided into the control group and the observation group with 40 cases in each group， according to the random number table method. The control group was treated with Pemetrexed alone， and the observation group was combined with Shenqi Fuzheng Injection on the basis of chemotherapy in the control group. The total effective rate， the tumor control rate， the incidence of adverse reaction， the sleep quality score and life quality score before and after treatment were compared. Results There were no statistically significant differences in total effective rate and tumor control rate between two groups （P>0.05）. The incidence of adverse reactions in the observation group （2.50%） was lower than that of the control group （27.50%）， and the difference was statistically significant （P<0.05）. Before treatment， the scores of sleep quality and life quality in two groups had no statistically significant differences （P>0.05）. After treatment， the score of sleep quality in the observation group was lower than that of the control group， the score of life quality was higher than that of the control group， and the differences between the groups were statistically significant （P<0.05）. Conclusion Pemetrexed combined with Shenqi Fuzheng Injection has some effect in the treatment of elderly patients with advanced lung adenocarcinoma， while combined treatment can effectively reduce the incidence of adverse reactions and significantly improve the prognosis of patients， which is worthy of clinical application.

[Key words] Pemetrexed； Shenqi Fuzheng Injection； Elderly； Advanced lung adenocarcinoma； Sleep quality score； Life quality score

肺腺癌是临床肺癌的一种，女性及不抽烟者为多发群体，有发病率高、病死率高、致残率高等特点[1]。据不完全统计[2-3]，患者经临床及影像学诊断确诊为肺腺癌时，60%患者的年龄>60岁，30%患者的年龄>70岁，且多为疾病晚期，无法通过手术实施治疗，针对该类患者，临床多采用化疗干预。但化疗药物在清除癌细胞过程中会导致患者的抵抗能力及免疫能力下降，从而影响其身体状态，故而有必要采取准确且合适的药物干预，对其身体状态提供保障[4]。本研究选取我院收治的80例老年晚期肺腺癌患者作为研究对象，旨在探讨培美曲塞联合参芪扶正注射液一线治疗该疾病的临床效果，现报道如下。