宋群路 何春红 张静云 胡爱飞

【摘 要】 目的：观察活血止痛方穴位贴敷治疗血脉瘀阻型下肢动脉硬化闭塞症（ASO）未溃期的临床疗效。方法：选取66例符合要求的ASO患者，随机分为治疗组和对照组各33例，后采用完全随机法在两组中各选出3例作为防脱落病例备用，不用于最后的疗效统计。对照组采用常规治疗加上安慰剂穴位贴敷的方法；治疗组采用常规治疗加上活血止痛方穴位贴敷的方法。观察并记录患者治疗前后典型症状体征积分、踝/肱比值（ABI）的变化和临床疗效。结果：治疗组总有效率为96.67%，明显优于对照组86.67%。症状体征积分及ABI与对照组相比，差异均有统计学意义（P<0.05）。结论：活血止痛方穴位贴敷治疗下肢动脉硬化闭塞症（ASO）未溃期血脉瘀阻证临床疗效较好，可在临床推广应用。

【关键词】 下肢动脉硬化闭塞症；血脉瘀阻证；活血止痛方；穴位贴敷

【中图分类号】R259 【文献标志码】 A【文章编号】1007-8517（2018）11-0096-04

Abstract：Objective To observe the clinical effect of acupoint application of Huoxue Zhitong prescription in treating lower extremity arteriosclerotic obliteration （ASO）.Methods Selection of 66 cases of ASO patients in accordance with the requirements，randomly divided into treatment group and control group of 33 cases，after that， 3 cases were selected from each of the two groups by the complete random method to be used as backup for the prevention of shedding cases，which is not for the final curative effect statistics.In the course of treatment ， the treatment group was treated with routine therapy plus the method of activating blood circulation and relieving pain ， and the control group treated with conventional therapy plus placebo acupoint application method . The typical clinical symptoms and ABI changes before and after treatment were observed and recorded .After the course of treatment， the statistical analysis was carried out with SPSS 17.0 software to evaluate the difference of clinical symptom score and clinical curative effect between the two groups.Results The total effective rate of the treatment group was 96.67%， which was significantly better than that of the control group （86.67%） .The clinical symptom observation indexes and ABI were significantly different from those of the control group （P<0.05）.Conclusion The acupoint application of Huoxue Zhitong prescription in treating lower extremity arteriosclerotic obliteration syndrome （ASO） has a remarkable clinical effect and has a high practicability in clinical practice.

Keywords：Arteriosclerosis Obliterans of Lower Extremity ；Blood Stasis Syndrome；Huoxue Zhitong Prescription；Acupoint Application

下肢動脉硬化闭塞症（Arterio Sclerosis Obliterans，ASO）是一种由于全身性动脉硬化而引起的慢性进展性闭塞性疾病，常为全身性动脉硬化血管病变在身体局部的表现，以下肢大中动脉居多。早期多由于下肢供血动脉硬化引起血管内膜增厚、管腔狭窄或者硬化斑块脱落成为游离栓子堵塞血管，最终导致病变肢体血供不足，引起下肢的困痛、乏力、水肿、间歇性跛行等，随着病情的发展甚至发生病变肢体远端的溃疡或坏死最终不得不选择截肢，病情严重者甚至还会有生命危险[1]。而在中医学，下肢动脉硬化闭塞症属于"“脉痹”、“脱疽”的范畴，又名“十指零落”，其名始见于《素问痹论》，本病多以气虚为本，血瘀为标，质属虚实夹杂。……