谢雄炳

[摘要] 目的 對消化性溃疡出血治疗中泮托拉唑联合内镜治疗的效果进行探讨。方法 便利选择该院2014年8月—2017年8月收治的消化性溃疡出血患者202例，依据随机数字表法分为实验组和常规组，每组101例。两组患者均接受常规治疗，常规组在此基础上接受泮托拉唑治疗，实验组在此基础上接受泮托拉唑联合胃镜治疗，统计并对比两组每日黑便次数、呕血次数、停止出血时间、治疗效果。结果 治疗后第1天实验组呕血次数（0.3±0.2）次，显著低于常规组的（0.5±0.3）次（t=3.508 2，P=0.000 8）。治疗后第1天实验组黑便次数（1.1±0.2）次，显著低于常规组的（1.5±0.3）次（t=7.016 5，P=0.000 0）。治疗后第2天，实验组黑便次数（0.2±0.1）次，显著低于常规组的（0.5±0.2）次（P=0.000 0，t=8.485 3）。治疗后第1天实验组出血量（163.3±17.9）mL，显著低于常规组的（250.7±25.2）mL（t=17.882 9，P=0.000 0）。第2天实验组出血量（13.3±2.4）mL，显著低于常规组的（24.3±4.2）mL（t=14.381 8，P=0.000 0）。第3天实验组出血量（2.1±0.3）mL，显著低于常规组的（4.3±1.5）mL（t=9.095 9，P=0.000 0）。实验组治疗总有效率98.02%，显著高于常规组的82.18%（χ2=3.472 2，P=0.025 3）。结论 应用泮托拉唑联合内镜治疗消化性溃疡出血效果显著，能够显著降低出血时间，减少黑便和呕血，具有较高推广价值。

[关键词] 泮托拉唑；内镜治疗；消化性溃疡出血

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2018）03（c）-0102-04

Study on Clinical Effect of Pantoprazole and Endoscope in Patients with Peptic Ulcer Bleeding

XIE Xiong-bing

Digestive System Department， Zhangzhou Zhengxing Hospital， Zhangzhou， Fujian Province， 363000 China

[Abstract] Objective To study the clinical effect of pantoprazole and endoscope in patients with peptic ulcer bleeding. Methods 202 cases of patients with peptic ulcer bleeding in our hospital from August 2014 to August 2017 were conveniently selected and randomly divided into two groups with 101 cases in each， both groups used the routine therapy， the routine group were treated with pantoprazole on the basis of the routine therapy， while the experimental group used the pantoprazole and endoscope on the basis of the routine therapy， and the melena frequency， haematemesis frequency， bleeding stopping time and treatment effect of the two groups were counted and compared. Results The haematemesis frequency in the experimental group was obviously lower than that in the routine group in 1 d after treatment， [（0.3±0.2）times vs （0.5±0.3）times]， （t=3.508 2，P=0.000 8）， the melena frequency in the experimental group was obviously lower than that in the routine group， in 1 d after treatment， [（1.1±0.2） vs （1.5±0.3）]， （P=0.000 0，t=7.016 5）， and the melena frequency in the experimental group in 2 d after treatment was obviously lower than that in the routine group， [（0.2±0.1） vs （0.5±0.2）]， （t=8.485 3，P=0.000 0）， and the bleeding amount in the experimental group in 1 d after treatment was obviously lower than that in the routine group[（163.3±17.9）mL vs （250.7±25.2）mL]， （t=17.882 9，P=0.000 0）， and the bleeding amount in the experimental group in 2 d was obviously lower than that in the routine group， [（13.3±2.4）mL vs （24.3±4.2）mL]， （t=14.381 8，P=0.000 0）， and the bleeding amount in the experimental group in 3d was obviously lower than that in the routine group， [（2.1±0.3）mL vs （4.3±1.5）mL]， （t=9.095 9，P=0.000 0）， and the total treatment effective rate in the experimental group was obviously higher than that in the routine group， （98.02% vs 82.18%），（χ2=3.472 2，P=0.025 3）. Conclusion The application effect of pantoprazole and endoscope in patients with peptic ulcer bleeding is obvious， which can obviously decrease the bleeding time， and reduce the melena and hematemesis， which is of higher promotion value.

[Key words] Pantoprazole； Endoscopic treatment； Peptic ulcer bleeding

消化性溃疡在消化内科具有较高发生率，主要存在消化道出血等并发症，严重者会因失血过多而休克或多器官功能衰竭，最终造成死亡。当前临床中针对消化性溃疡出血患者多采取质子泵抑制剂静脉注射治疗，进而达到抑制胃酸分泌的目的。但该治疗方法通常止血速度较慢，相关研究认为应用泮托拉唑联合……