冯海霞

[摘要] 目的 无排卵性月经失调应用不同剂量黄体酮治疗的临床影响效果探讨。方法 方便选取该院于2016年6月—2017年6月收治的无排卵性月经失调患者80例，按数字法分组：A组与B组，各40例。大剂量黄体酮用于A组，小剂量黄体酮用于B组，对2组患者治疗前后的子宫内膜厚度情况与停药出血状况以及临床疗效状况和不良反应发生情况进行观察比较。结果 2组患者治疗前的子宫内膜厚度情况与停药出血状况比较差异无统计学意义；治疗后，2组患者的子宫内膜厚度及出血持续时间明显减少，但组间差异无统计学意义（P>0.05）。B组的总有效率高于A组（95.00%>85.00%）差异无统计学意义（P>0.05）；而A组的不良反应发生率比B组高（22.50%>5.00%）差异无统计学意义（P<0.05）。结论 无排卵性月经失调应用小剂量药物治疗的不良反应发生率比更小剂量药物治疗低，因而选择小剂量黄体酮治疗的应用效果更为理想，值得推广。

[关键词] 无排卵性月经失调；不同剂量；黄体酮；临床效果

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2018）03（c）-0021-03

Analysis of Comparison of Clinical Effect of Different Doses of Progesterone in Anovulatory Menoxenia

FENG Hai-xia

Department of Gynecology and Obstetrics， Linzi District Maternal and Infant Healthcare Hospital， Zibo， Shandong Province， 255400 China

[Abstract] Objective To study the clinical effect of different doses of progesterone in anovulatory menoxenia. Methods 80 cases of patients with anovulatory menoxenia admitted and treated in our hospital from June 2016 to June 2017 were convenient selected and randomly divided into two groups with 40 cases in each， the group A and the group B respectively used the large-dose and small-dose progesterone， and the endometrium thickness， drug withdrawal and bleeding， clinical curative effect， and occurrence of adverse reactions were observed and compared. Results The differences in the endometrium thickness and drug withdrawal and bleeding between the two groups before the treatment were not obvious， after treatment， the endometrium thickness and duration of bleeding of the two groups obviously decreased， and the difference between groups was not statistically significant（P>0.05）， and the total effective rate in the group B was higher than that in the group A （95.00%>85.00%），the difference was not statistically significant（P>0.05）； and the incidence rate of adverse reactions in the group A was higher than that in the group B（22.50%>5.00%），the difference was statistically significant（P<0.05）. Conclusion The incidence rate of adverse reactions of small-dose drug in treatment of anovulatory menoxenia is lower than that of smaller-dose drugs， therefore， the application effect of small-dose progesterone is more ideal， which is worth promotion.

[Key words] Anovulatory menoxenia； Different doses； Progesterone； Clinical effect

无排卵性月经失调是一种比较常见的妇科疾病，患者发病时多表现为月经周期短、月经频发、黄体期缩等[1]。无排卵性月经失调影响患者的受孕，甚至引发孕早期流产等并发症，最终阻碍了患者的身心健康发展[2]。近年来，无排卵性月经失调患者的患病率逐年递增，已经发展成为临床研究的重要课题之一[3]。黄体功能替代疗法是一种较为高效的治疗方式，通常选取天然黄体酮制剂进行治疗，以此补充黃体分泌孕酮的不足，采用黄体酮制剂进行用药治疗，可以有效降低出血量，使月经周期恢复正常[4]。该文研究中，该院将80例于2016年6月—2017年6月入院的采用无排卵性月经失调患者分为2组，采取不同剂量黄体酮进行治疗，现报道如下。