罗倩

摘 要：目的 研究慢性阻塞性肺疾病急性加重期患者的肺功能指标、血气以及炎性指标的变化，为临床制定诊疗方案提供参考依据。方法 将我院2014年1月～2016年10月呼吸内科收治的42例慢阻肺急性加重期患者纳入A组，对其采用相应的治疗措施，另选取42例同期收治的慢阻肺稳定期患者纳入B组，并选取同期42例正常体检者为对照组。对三组患者的肺功能指标、血气分析以及炎性指标进行分析对比。结果 A组、B组三项指标均比正常体检者低，差异有统计学意义（P<0.05）；A组三项指标均低于B组，差异有统计学意义（P<0.05）；血气指标、炎性因子表达变化与急性加重期患者肺功能改变均具有相关性（P<0.05）。结论 急性加重期患者肺功能、血气及炎性指标与其他分期或健康者有较大的差异，在临床上需要对病情进行详尽分析，确定合适的治疗方案。

关键词：慢性阻塞性肺疾病；加重期；肺功能；血气

中图分类号：R563.9 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.09.034

文章编号：1006-1959（2018）09-0114-03

Abstract：Objective To study the changes of pulmonary function， blood gas and inflammatory indexes in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）and to provide reference for clinical diagnosis and treatment.Methods 42 patients with acute exacerbation of COPD admitted in our hospital from January 2014 to October 2016 were included in group A and treated with corresponding treatment measures.Another 42 patients with stable chronic obstructive pulmonary disease admitted in the same period were included in the group B.42 cases of normal physical examination were selected as control group in the same period.Pulmonary function index，blood gas analysis and inflammatory index were analyzed and compared among the three groups.Results The three indexes of group A and group B were lower than those in normal physical examination，the difference is statistically significant（P<0.05）.The three indexes of group A were lower than those in group B，the difference is statistically significant（P<0.05）.The changes of blood gas index，inflammatory factor expression and pulmonary function were correlated with acute exacerbation（P<0.05）.Conclusion The pulmonary function， blood gas and inflammatory indexes in patients with acute exacerbation are different from those in other stages or healthy persons.It is necessary to make a detailed analysis of the condition in clinical practice and determine the appropriate treatment plan.

Key words：Chronic obstructive pulmonary disease；Exacerbation；Pulmonary function；Blood gas

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）是呼吸科常見的一种肺部疾病，临床上以不完全可逆的气流受限为特征，常呈进行性发展最终发展为破坏性疾病[1]，尤其是在急性加重期常常会有严重的临床表现，导致患者生活质量显著下降。长期临床实践发现，慢阻肺的发生与机体免疫功能下降存在明显相关性。而炎症指标、血气指标、肺功能改变均会导致患者机体免疫功能下降。故推测这些因素在慢阻肺患者病情发展中也可能发挥着作用。故本次研究对84例慢阻肺患者进行分析，探讨加重期患者相关指标的变化。

1 资料与方法

1.1一般资料 选取2014年1月～2016年10月贵航贵阳医院呼吸内科收治的42例慢阻肺急性加重期患者纳入A组，另选取42例同期收治的慢阻肺稳定期患者纳入B组，选取同期42例正常体检者为对照组。本研究经本院医学伦理委员会审批通过。……