李明 龙海燕

[摘要] 目的 探討布地奈德联合氨溴索雾化吸入应用在儿童肺炎治疗中的临床效果及安全性。方法 方便选取该院于2016年2月—2017年3月收治的小儿肺炎患者184例，并随机分为两组，实验组和对照组各92例，对照组患者实施单纯氨溴索雾化吸入治疗，实验组患者实施布地奈德联合氨溴索雾化吸入治疗，记录并比较两组患者的治疗有效率、体温恢复时间以及不良反应发生率等临床指标。结果 两组患者的治疗有效率比较，实验组患者的总有效率为97.83%，显著高于对照组的86.96%，且差异有统计学意义（P<0.05）；两组患者的各项指标比较，实验组患者的体温恢复时间、止咳时间为（4.61±1.67）、（2.12±0.43）d，均显著低于对照组的（5.86±1.71）、（4.22±0.89）d，且差异有统计学意义（P<0.05）；实验组患者的并发症发生率为5.43%（5例），对照组患者为7.61%（7例），两组比较差异无统计学意义（P>0.05）。结论 布地奈德联合氨溴索雾化吸入应用在儿童肺炎治疗中的临床效果良好，可以显著降低患者的体温恢复时间、止咳时间等，提高了治疗效果，且无严重并发症发生，因此具有较高安全性，值得临床推广应用。

[关键词] 布地奈德；氨溴索；雾化吸入；儿童肺炎；临床效果

[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0131-03

Efficacy of Budesonide Combined with Ambroxol Inhalation in Children with Pneumonia

LI Ming， LONG Hai-yan

Department of Pharmacy， Xishuangbanna Peoples Hospital， Xishuangbanna， Yunnan Province， 666100 China

[Abstract] Objective This paper tries to investigate the clinical effect of budesonide combined with ambroxol hydrochloride inhalation and safety in application in the treatment of children with pneumonia. Methods 184 children with pneumonia in the hospital from February 2016 to March 2017 were conveniently selected， and randomly divided into two groups， experimental group and control group with 92 cases in each group， the control group was treated with ambroxol alone inhalation therapy， aerosol inhalation of budesonide combined with ambroxol treatment of patients in the experimental group， to record and compare two groups of patients with treatment efficiency， temperature recovery time and the incidence of adverse reactions and other clinical indicators. Results The total effective rate of the patients in the two groups was 97.83%， significantly higher than 86.96% in the control group， and the difference was statistically significant （P<0.05）. Each index of two groups of patients， the experimental group with temperature recovery time， cough time were （4.61±1.67）， （2.12±0.43）d， were significantly lower than the control group of（5.86±1.71），（4.22±0.89）d， and the difference was statistically significant （P<0.05）； The incidence of complications in the experimental group was 5.43%（5 cases） and 7.61%（7 cases） in the control group， with no statistically significant difference between the two groups （P>0.05）. Conclusion The clinical effect of budesonide combined with ambroxol hydrochloride inhalation in treatment of children with pneumonia is good， which can significantly reduce the patients with recovery time of body temperature， cough time， improve the treatment effect， without serious complications， so it has high safety， and it is worthy of clinical application.

[Key words] Budesonide； Ambroxol； Inhalation； Pneumonia in children； Clinical effect

呼吸系统疾病肺炎于儿科之中是一类较为常见的病症，婴儿幼童患病者数量较多，由于小儿肺炎患者免疫系统功能较薄弱，极易引发憋喘性肺炎等严重并发症，严重威胁患者的生命健康[1]。肺炎患者临床多表现为呼吸急促、发热、干咳等，部分患者出现深呼吸时胸痛，严重者甚至出现咳血。而小儿肺炎患者在患病后的临床表现并不显著，多表现为发热、呼吸困难等，而且小儿肺炎还具有较高传染性，严重影响儿童的健康成长。目前对于小儿肺炎的临床治疗多为基本的清痰处理和静脉注射药物治疗。……