杨俊+++周旭辉++郭育君+罗琼

[摘要] 目的 探討男性酒精依赖患者认知功能与红细胞相关指标的关系。 方法 选择2016年1月～2017年4月湖南省脑科医院收治的65例男性酒精依赖患者为研究组，65例健康体检者为对照组，采用蒙特利尔认知评估量表（MoCA）评价认知功能，全自动生化分析仪检测丙氨酸氨基转氨酶（ALT）、天冬氨酸氨基转移酶（AST）和γ-谷氨酞基转移酶（GGT）含量，全自动五分类血液细胞分析仪分析红细胞数（RBC）、血红蛋白浓度（HGB）、血细胞比容（HCT）、红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和平均血红蛋白浓度（MCHC）等红细胞参数。 结果 研究组患者MoCA评分显著低于对照组，肝功能指标ALT、AST和GGT显著高于对照组，差异有统计学意义（P < 0.05）。研究组患者RBC、HGB和HCT显著低于对照组，差异有统计学意义（P < 0.05）。两组患者MCV、MCH和MCHC比较，差异无统计学意义（P > 0.05）。研究组患者MoCA评分与RBC、HGB和HCT呈正相关（r=0.61、0.63、0.72，P < 0.05），与MCV、MCH和MCHC无相关性（P > 0.05）。研究组患者ALT与RBC、HGB和HCT呈负相关（r=-0.63、-0.65、-0.73，P < 0.05），与MCV、MCH和MCHC无相关性（P > 0.05），AST和GGT与红细胞相关指标无相关性（P > 0.05）。 结论 男性酒精依赖患者认知功能与红细胞相关指标均发生改变，认知功能与红细胞相关指标密切相关。

[关键词] 酒精依赖；认知功能；红细胞指标；相关性

[中图分类号] R749.6 [文献标识码] A [文章编号] 1673-7210（2017）09（b）-0102-04

Clinical study on the relation of cognitive function and red blood cell index in male patient with alcohol dependence

YANG Jun ZHOU Xuhui GUO Yujun LUO Qiong

Alcohol Addiction and Internet Addiction Psychiatry Department， Hu′nan Province Brain Hospital， Hu′nan Province， Changsha 410007， China

[Abstract] Objective To study the correlation of cognitive function and red blood cells index in male patients with alcohol dependence. Methods 65 male patients with alcohol dependence were selected as research group in Hu′nan Province Brain Hospital from January 2016 to April 2017， and 65 healthy check-up were selected as control group. The cognitive function were assessed by Montreal cognitive ment scale （MoCA）， the content of alanine aminotransferase （ALT）， aspartate aminotransferase （AST） and gamma-pancreatic phthalein transferase （GGT） were tested by automatic biochemical analyzer， the red blood cell count （RBC）， hemoglobin （HGB）， hematocrit （HCT）， red cell volume （RCV）， average red blood cell hemoglobin content （MCH） and hemoglobin concentration （MCHC） were detected by fully automatic classification of five blood cell analyzer. Results The score of MoCA in research group was significantly lower than that in control group， and the liver function index of ALT， AST and GGT were significantly higher than that in control group， the differences were statistically significant （P < 0.05）. The RBC， HGB and HCT in research group were significantly lower than that in control group， the differences were statistically significant （P < 0.05）. RCV， MCH and MCHC in two groups were no statistically significant difference （P > 0.05）. The score of MoCA in research group was positive related to RBC， HGB and HCT （r = 0.61， 0.63， 0.72， P < 0.05）. There were no correlation between MoCA score and MCV， MCH and MCHC in research group （P > 0.05）. ALT in research group was negatively related to RBC， HGB and HCT （r =-0.63， -0.65， -0.73， P < 0.05）. There was no correlation between ALT and MCV， MCH and MCHC in research group （P > 0.05）. AST and GGT were not correlated with erythrocyte correlation （P > 0.05）. Conclusion The cognitive function and red blood cells index in male patients with alcohol dependence are changed， the cognitive function and red blood cells index are closely related.endprint

[Key words] Alcohol dependence； Cognitive function； Index of red blood cells； Correlation

随着人民生活水平提高和膳食结构变化及各种酒类出现频率的与日俱增，对饮酒者躯体及精神带来较多的损害，甚至导致严重不良后果[1]。长期大量摄入酒精除了常见的脂质代谢障碍、酒精性肝硬化、血清尿酸水平升高、心血管疾病等外，酒精依赖已成为世界性的公共卫生问题[2-5]。酒精依赖患者常合并多种躯体疾病，其中以肝功能异常和贫血最常见，严重肝功损害可加重贫血，引起患者红细胞免疫功能、红细胞变形性及能量代谢变化，红细胞相关指标的变化进一步加重患者的病情，导致大脑损害及认知功能下降[6-7]。因此……