儿童传染性单核细胞增多症118例临床分析
2017-10-17朱加进伍万陈云龙
朱加进 伍万 陈云龙
[摘要] 目的 分析儿童传染性单核细胞增多症的临床症状和体征及实验室检验结果,帮助提高诊疗水平。 方法 回顾性分析2014年7月~2016年6月入院的118例IM患儿的临床资料。 结果 研究发现本组患儿中1~8岁患病最多,共95例(80.5%);除1例疑似EB病毒相关性嗜血综合征病例,其余大多预后良好。临床症状以三联征包括发热(98.3%)、咽峡炎(78.0%)、颈淋巴结肿大(72.9%)最常见,肝脏肿大者占55.9%,脾脏肿大占48.3%,皮疹占36.4%,打鼾和眼睑浮肿占52.5%。实验室检查:112例白细胞(WBC)计数>10×109/L(94.9%),淋巴细胞比例>35%的患者有108例(91.5%),>50%的有86例(72.9%),异型淋巴细胞比例>10%者占70.3%,谷丙转氨酶升高者占58.5%,EB病毒(EBV)的IgM抗体(EBV-CA-IgM)阳性率66.1%。 结论 儿童传染性单核细胞增多症可造成多系统功能损害,临床表现复杂,可结合实验检验结果对IM有更全面的认识。
[关键词] 传染性单核细胞增多症;儿童;临床症状和体征;实验室检验结果
[中图分類号] R725.1 [文献标识码] B [文章编号] 1673-9701(2017)24-0075-04
[Abstract] Objective To analyze the clinical symptoms, signs and laboratory test results of infectious mononucleosis (IM) in children and to improve the level of diagnosis and treatment. Methods The clinical data of 118 children with IM who were admitted to our hospital from July 2014 to June 2016 were retrospectively analyzed. Results The study found that the children patients with 1 to 8 years old were the most in the group, with a total of 95 cases(80.5%); in addition to one case of suspected EBV-associated bloodthirsty syndrome, most of the other children had a good prognosis. Clinical symptoms were mostly seen in triple syndromes including fever(98.3%), angina(78.0%), and cervical lymphadenopathy (72.9%). Liver enlargement accounted for 55.9%, spleen enlargement accounted for 48.3%, rash accounted for 36.4%, snoring and eyelid edema accounted for 52.5%. Laboratory examination: 112 cases of white blood cells (WBC) count>10×109/L(94.9%). There were 108 cases (91.5%) with the proportion of lymphocyte> 35%, and 86 cases (72.9%) with the proportion >50%. The cases with the proportion of abnormal lymphocyte >10% accounted for 70.3%. The cases with increased alanine aminotransferase accounted for 58.5%. The positive rate of IgM antibody(EB virus capsid antigen IgM, EBV-CA-IgM) of EB virus (Epstein-Barr virus) was 66.1%. Conclusion Infectious mononucleosis in children can cause multiple system dysfunction, with complex clinical manifestations, which can be comprehensively understood via experiment test results.
[Key words] Infectious mononucleosis (IM); Children; Clinical symptoms and signs; Laboratory test results
传染性单核细胞增多症(infectious mononucleosis,IM)是以机体单核巨噬细胞系统增生为特点的,好发于儿童的常见病,一般多由EB病毒(Epstein-Barr virus,EBV)感染所致,病程常有自限性,表现为以“发热、咽峡炎和颈部淋巴结肿大”为特点的三联征,也可合并肝脾的肿大和外周血淋巴细胞、异型淋巴细胞增高[1];本研究是将我院儿科A病区2年收入院的IM患者临床资料总结回顾性分析如下。
1 资料与方法
1.1 一般资料
2014年7月~2016年6月收治的IM患者118例,其中男57例(占48.3%),女61例(占51.7%),最小者9个月,最大者14岁,≤1岁23例(占19.5%),1~4岁56例(占47.5%),4~8岁29例(占24.6%),8~12岁7例(占5.9%),≥12岁3例(占2.5%);发病季节:春季(3~5月)28例(占23.7%),夏季(6~8月)40 例(占33.9%),秋季(9~11月)33例(占28.0%),冬季(12~2月)17例(占14.4%)。endprint……
