刘慧巧　陶静　汤剑芳

[摘要] 目的 探讨伴2型糖尿病突发性耳聋患者应用甲泼尼龙琥珀酸钠耳后注射治疗的临床效果。 方法 对我院2015年10月～2017年4月期间收治的88例伴2型糖尿病突发性耳聋患者进行分组研究，根据随机原则分为对照组和观察组，每组各44例。对照组患者予以地塞米松鼓室内注射治疗，观察组患者予以甲泼尼龙琥珀酸钠耳后注射治疗，对两组患者的临床疗效、各频率听阈改善情况及血糖控制情况进行统计对比。 结果 观察组治疗总有效率为95.5%，明显高于对照组的77.3%，差异有统计学意义（P<0.05）。治疗后，在0.5 kHz、1.0 kHz、2.0 kHz、4.0 kHz方面，观察组听阈改善情况均优于对照组，差异有统计学意义（P<0.05）。治疗后，在空腹血糖、餐后2 h血糖方面，两组比较差异无统计学意义（P>0.05）。 结论 甲泼尼龙琥珀酸钠耳后注射治疗伴2型糖尿病突发性耳聋的临床效果确切，可明显改善患者的听阈情况，值得临床推广应用。

[关键词] 突发性耳聋；2型糖尿病；甲泼尼龙琥珀酸钠；耳后注射

[中图分类号] R587.1；R764.437 [文献标识码] B [文章编号] 1673-9701（2017）24-0082-03

[Abstract] Objective To investigate the clinical effect of retroauricular injection of methylprednisolone sodium succinate in the patients with type 2 diabetes mellitus complicated with sudden deafness. Methods 88 patients with type 2 diabetes mellitus complicated with sudden deafness who were admitted to our hospital from October 2015 to April 2017 were divided into groups. According to the randomized principle， the patients were divided into control group and observation group， with 44 cases in each group. The patients in the control group were given intravesical injection of dexamethasone， and the patients in the observation group were given retroauricular injection of methylprednisolone sodium succinate. The clinical efficacy， the improvement of the frequency of hearing threshold and blood glucose control were statistically analyzed and compared between the two groups. Results The total effective rate was 95.5% in the observation group， which was significantly higher than that in the control group（77.3%）， and the difference was statistically significant（P<0.05）. After treatment， in terms of 0.5 kHz， 1.0 kHz， 2.0 kHz， 4.0 kHz， the hearing threshold improvement in the observation group was better than that in the control group， and the difference was statistically significant（P<0.05）. After treatment， in terms of fasting blood glucose and 2 h postprandial blood glucose， the differences were no statistically significant between the two groups（P>0.05）. Conclusion The clinical effect of retroauricular injection of methylprednisolone sodium succinate in the treatment of type 2 diabetes mellitus complicated with sudden deafness is exact， which is able to significantly improve the hearing threshold of the patients， and is worthy of clinical promotion and application.

[Key words] Sudden deafness；Type 2 diabetes mellitus；Methylprednisolone sodium succinate；Retroauricular injection

突發性耳聋指的是突然发生的、原因不明的感音神经性听力损失，临床表现主要有单侧听力下降，同时伴有恶心、呕吐、耳鸣、眩晕及耳堵塞感等症状，属于耳鼻喉科急症，应给予快速及时的治疗，合理用药[1]。目前，多数医师均认可激素治疗效果。但是针对伴2型糖尿病突发性耳聋患者而言，激素不能全身应用，既往临床多采用鼓室内局部注射，尽管具有一定的治疗效果，但易发生鼓室内纤维组织增生、瘢痕粘连等情况，致使治疗效果受到影响。因此，应积极探索更加有效、安全的治疗方法[2，3]。本文通过对我院2015年10月～2017年4月期间收治的88例伴2型糖尿病突发性耳聋患者的分组研究，探讨甲泼尼龙琥珀酸钠的治疗效果，并提出有效的护理对策，现报道如下。……