唐玲荣，李光，党军，纪天龙，姚雷

（中国医科大学附属第一医院放射治疗科，沈阳 110001）

hMOF蛋白在食管癌中的表达及其与放射治疗预后的关系

唐玲荣，李光，党军，纪天龙，姚雷

（中国医科大学附属第一医院放射治疗科，沈阳 110001）

目的探讨人类第一雄性缺失（hMOF）蛋白在食管癌中的表达特点及其与放射治疗（简称放疗）预后的关系。方法应用免疫组化方法检测13对食管癌及癌旁正常组织和90例放疗前食管癌活检组织中hMOF蛋白的表达情况，按染色评分分为低表达和高表达组，分析hMOF蛋白表达水平与放疗预后的相关关系。结果正常食管组织及食管癌组织中均有hMOF蛋白表达，hMOF蛋白在食管癌中的表达水平明显高于正常组织，差异有统计学意义（P ＜ 0.05）；生存分析显示hMOF蛋白表达水平、化疗情况是食管癌放疗的独立预后因素；患者同期放化疗1、3、5年生存率高于序贯化疗及单纯放疗，hMOF蛋白高表达的食管癌患者放疗后生存率低于低表达者。结论hMOF蛋白表达水平与食管癌的放疗预后有关，可作为评价食管癌放疗预后的新指标。

人类第一雄性缺失蛋白； 食管癌； 放射治疗预后； 免疫组化

Abstract ObjectiveTo examine human males absent on the first （hMOF） protein expression in patients with esophageal cancer and explore its correlation with radiotherapy prognosis.MethodsPrior to radiotherapy，hMOF protein expression levels were examined using immunohistochemistry，in 13 pairs of esophageal cancer tissues and adjacent，non-tumorous，esophageal tissues，as well as in 90 esophageal cancer biopsy tissues. The hMOF protein expression level was classified into a high-expression group and a low-expression group，based on immunohistochemical staining scores. The correlation between these groups and radiotherapy prognosis was analyzed.ResultsBoth esophageal cancer tissues and adjacent，non-tumorous，esophageal tissues displayed hMOF protein expression，although a significantly higher level of hMOF expression was found in esophageal cancer tissues （P ＜ 0.05）. Survival analysis showed that hMOF protein expression and chemotherapy were independent prognostic factors. The 1-，3-，and 5-year survival rates of patients receiving concurrent chemoradiotherapy were higher than the survival rates in patients receiving sequential chemotherapy or radiotherapy alone. The survival rate after radiotherapy was lower in the high hMOF expression group than in the low-expression group.ConclusionhMOF protein expression may be involved in the development and tumorigenesis of esophageal cancer. In patients with esophageal cancer，hMOF could be used as a new radiotherapy prognostic marker.

Keywordshuman males absent on the first protein； esophageal cancer； radiotherapy prognosis； immunohistochemistry

我国食管恶性肿瘤发病率较高，且逐渐有升高趋势［1］。放射治疗（简称放疗）是治疗食管恶性肿瘤的主要方式之一。单纯放疗5年生存率不足10%，近年来随着同期放化疗的应用，5年生存率有了较大幅度的提高［2］。

肿瘤放射敏感性是影响放疗疗效的主要生物学因素。人类第一雄性缺失（human males absent on the first，hMOF）蛋白是乙酰基转移酶MYST家族成员之一。……