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补气通络方治疗气虚痰瘀阻络型脑梗死恢复期的临床疗效研究

徐中菊，舒适，陈宝瑾，黄金阳

目的观察补气通络方治疗气虚痰瘀阻络型脑梗死恢复期的临床疗效及其对血液流变学指标的影响。方法将60例气虚痰瘀阻络型脑梗死恢复期病人随机分为两组。对照组30例，予西医常规治疗；治疗组30例，在对照组治疗的基础上加用补气通络方口服。两组均治疗2个月为 1 个疗程，1 个疗程后评定临床疗效，观察两组治疗前后血液流变学指标及神经功能缺损评分和日常生活能力(Barthel)指数评分变化。结果治疗组总有效率86.67%，对照组总有效率63.33%，治疗组疗效优于对照组(P<0.05)。两组治疗后神经功能缺损评分及Barthel指数均较前改善，治疗组治疗后改善程度较对照组更为显著(P<0.05)；治疗组治疗后血液流变学指标显著低于治疗前及对照组并具有统计学意义。结论补气通络方能有效改善气虚痰瘀阻络型脑梗死恢复期病人的血液流变学、神经功能缺损评分和日常生活能力指数评分等指标，促进病人神经功能康复，提高日常生活能力，且安全无毒副作用。

脑梗死恢复期；补气通络方；气虚痰瘀阻络；血液流变学； 神经功能缺损；日常生活能力

Abstract:ObjectiveTo investigate the effect of Buqi Tongluo prescription (BTP) in the treatment of cerebral infarction at convalescence with qi deficiency and phlegm and blood stasis syndrome.MethodsSixty patients with cerebral infarction at convalescence with qi deficiency and phlegm and blood stasis syndrome were randomly divided into two groups：control group (n=30) treated with routine treatment，and treatment group (n=30) treated with BTP in the basis of routine treatment for 2 months. The clinical effect was evaluated after a course. The changes of blood rheology， nerve function defect score and Barthel indexe before and after treatment were observed.ResultsThe total clinical effective rate was 86.67% in treatment group，which was significantly higher than that in control group (63.33%，P<0.05). There was significant difference in blood rheology，nerve function defect and Barthel indexe between two groups before and after treatment (P<0.05). The changes in treatment group was more obvious than that in control group (P<0.05)．ConclusionBTP can effectively improve blood rheology，nerve function defect，and activities of daily living， promote the recovery in patients with cerebral infarction at convalescence with qi deficiency and phlegm and blood stasis syndrome.

Keywords：cerebral infarction at convalescence；Buqi Tongluo prescription；qi deficiency and phlegm and blood stasis syndrome；blood rheology；nerve function defect；activities of daily living

随着生活水平的不断提高和生活方式的改变，脑梗死发病率快速上升，国内外大型临床研究数据显示，中风流行病学发病率为2.9%，其中脑梗死引起的缺血性中风占全部中风的87%[1-2]。脑梗死病人经积极临床救治后，存活率明显提高，但通常会留有偏瘫、失语等不同程度的后遗症，因此脑梗死恢复期的治疗直接影响着脑梗死病人的生活质量及其预后。近年来，采用经验方补气通络方治疗脑梗死恢复期病人取得了较好疗效，为进一步研究其在脑梗死恢复期治疗中的临床疗效和可能机制，本研究采用西医常规治疗的基础上合用补气通络方治疗气虚痰瘀阻络型脑梗死恢复期，且病人30例，并与西医常规治疗30例对照观察，现报道如下。……