刘莉莉　任长安

[摘要] 目的 观察补肾活血除湿法治疗免疫性不孕不育患者的临床疗效。 方法 选取2015年1月～2016年1月我院收治的免疫性不孕不育患者80例，根据治疗方式的不同分为观察组（40例，给予补肾活血除湿法治疗）、对照组（40例，给予西药治疗）。观察两组患者的临床总有效率、不良反应发生率、阳性抗体转阴情况。治疗前后，检测内分泌指标（促卵泡生成素、雌二醇）水平。 结果 观察组临床总有效率为97.50%、总不良反应发生率为2.50%、阳性抗体总转阴率为97.50%，均优于对照组患者的临床总有效率62.50%、总不良反应发生率15.00%、阳性抗体总转阴率85.00%（P<0.05）。治疗后，两组促卵泡生成素均显著下降，雌二醇显著上升，且组间比较存在显著差异（P<0.05）。 结论 免疫性不孕不育患者应用补肾活血除湿法治疗疗效显著，可有效改善性激素指标，提高受孕率，临床上值得推广。

[关键词] 补肾活血除湿法；免疫性不孕不育；中医；促卵泡生成素；雌二醇

[中图分类号] R271.14 [文献标识码] B [文章编号] 1673-9701（2017）16-0109-03

[Abstract] Objective To observe the clinical effect of Bushenhuoxuechushi method in the treatment of immune infertility patients. Methods 80 patients with immunodeficient infertility in our hospital from January 2015 to December 2016 were selected. According to the different treatment methods， the patients were divided into observation group（n=40） treated with Bushenhuoxuechushi method and control group（n=40） given Western medicine treatment. The clinical total effective rate， the incidence of adverse reactions and turning antibody from positive to negative were observed in the two groups of immunological infertility patients. The levels of endocrine indicators（follicle stimulating hormone， estradiol） were detected before and after treatment. Results The total effective rate 97.50%， the total adverse reactions rate 2.50%， the total rate of turning antibody from positive to negative 97.50% in the observation group were superior to the total effective rate 62.50%， the total adverse reaction rate 15.00%， the total rate of turning antibody from positive to negative 85.00% in the control group（P<0.05）. After treatment， the follicle-stimulating hormone in the two groups decreased significantly， the estradiol increased significantly. And there was significant difference between the two groups （P<0.05）. Conclusion The application of Bushenhuoxuechushi method in treatment of patients with immune infertility is significantly effective， which can improve the sex hormone indexes， improve the pregnancy rate， and is worthy of promotion in clinical.

[Key words] Bushenhuoxuechushi method； Immune infertility； Traditional Chinese medicine； Follicle-stimulating hormone； Estradiol

不孕不育是指在未采取避孕措施和婚后有正常的性生活的情況下，婚后1年以上而未受孕[1]。免疫性不孕不育是指生殖系统抗原的自身免疫或同种免疫引起的不孕不育[2，3]。本文主要观察补肾活血除湿法治疗免疫性不孕不育患者的临床疗效，将免疫性不孕不育患者分为两组进行研究，现报道如下。

1 资料与方法

1.1 临床资料

选取我院2015年1月～2016年1月收治的免疫性不孕不育患者80例，根据治疗方式的不同分为观察组（40例，给予补肾活血除湿法治疗）和对照组（40例，给予西药治疗）。观察组患者年龄21～41岁，平均（35.10±2.33）岁；文化程度：初中以下15例、初中以上13例、大专以上12例。对照组患者年龄20～42岁，平均（35.20±2.30）岁；文化程度：初中以下14例、初中以上15例、大专以上11例。80例患者均符合免疫性不孕不育的诊断标准，并同意参加研究，签署知情同意书。……