程云帆++余晓岚++蒋小玲?商永华?王亭如

[摘要] 目的 研究健脾益氣补血法治疗气血亏虚型帕金森病胃肠功能障碍患者生活质量的疗效。方法 将选取2015年5月～2016年11月期间的67例气血亏虚型帕金森病胃肠功能障碍患者随机分为两组，对照组35例予神经内科常规治疗，治疗组32例在神经内科常规治疗基础上予健脾益气补血汤煎服治疗。以统一帕金森病评定量表第三部分（UPDRSⅢ）、帕金森病测量问卷（PDQ-39）、胃肠道症状积分及中医老年颤证诊断和疗效评定标准判定疗效。 结果 治疗后两组UPDRSⅢ、帕金森病测量问卷（PDQ-39）、胃肠道症状积分评分均有下降，治疗组较对照组更明显（P<0.05）。治疗组总有效率为96.8%，对照组为77.1%，两组临床总有效率差异有统计学意义（P<0.05）。结论 气血亏虚型帕金森病胃肠功能障碍予健脾益气补血法治疗效果明显。

[关键词] 帕金森病；胃肠功能障碍；生活质量；气血亏虚型；健脾益气补血法

[中图分类号] R742.5 [文献标识码] A [文章编号] 2095-0616（2017）07-16-04

Effect of strengthening spleen and replenishing qi and enriching blood method on quality of life of Parkinson patients with gastrointestinal dysfunction

CHENG Yunfan YU Xiaolan JIANG Xiaoling SHANG Yonghua WANG Tingru

Fuzhou Second Hospital， Affiliated to Xiamen University， Fuzhou 350007， China

[Abstract] Objective To study the curative effect of strengthening spleen and replenishing qi and enriching blood method on quality of life of qi-blood deficiency Parkinson patients with gastrointestinal dysfunction. Methods 67 qi-blood deficiency Parkinson patients with gastrointestinal dysfunction who were admitted to our hospital from May 2015 to November 2016 were randomly divided into two groups. Results 35 patients in the control group were given routine treatment in Department of Neurology. 32 patients in the observation group were treated by strengthening spleen and replenishing qi and enriching blood decoction at the basis of routine treatment in Department of Neurology. Curative effects were evaluated by the third part of unified Parkinson's disease rating scale （UPDRSⅢ）， Parkinson's disease questionnaire （PDQ-39）， gastrointestinal symptom score and diagnostic and efficacy evaluating standard of Chinese medical elderly tremor syndrome. Scores of UPDRSⅢ， Parkinson's disease questionnaire （PDQ-39）and gastrointestinal symptom were all decreased. And those of the treatment group were more significant than those of the control group （P<0.05）. Total effective rates of the treatment group and the control group were respectively 96.8% and 77.1% and the difference between two groups was statistically significant （P<0.05）. Conclusion Strengthening spleen and replenishing qi and enriching blood method in treatment of qi-blood deficiency Parkinson patients with gastrointestinal dysfunction has significant curative effect.

[Key words] Parkinson disease； Gastrointestinal dysfunction； Quality of life； Qi-blood deficiency； Strengthening spleen and replenishing qi and enriching blood metho

帕金森病（PD）一种常见的中枢神经系统变性疾病，随着我国人口老龄化，其患病率也呈上升的趋势，PD有运动障碍和非运动障碍症状，PD在非运动症状的自主神经障碍中以消化道功能障碍的表

现较常见，流涎、吞咽困难、胃排空延迟、便秘等胃肠功能障碍最常见，严重影响患者的生活质量[1]。而众多研究认为，PD患者存在胃肠功能障碍的原因与此类患者的咀嚼肌、食管肌肉张力降低有关，同时此类患者的胃肠道神经元细胞变性，从而导致胃肠动力不足，因此胃排空等情况表现明显，同时较多疾病治疗药物对患者的胃肠动力也造成一定的不良影响，进一步加重了胃肠功能障碍的严重程度。因此临床中对于帕金森病胃肠功能障碍患者的治疗需求较高。……