刘杰锋?吴炳卓?黄丽嫦?钟春媚?陈艳清?李诗海

[摘要] 目的 探讨溃疡性结肠炎（UC）患者白介素-6（IL-6）、白介素-8（IL-8）及肿瘤坏死因子（TNF-α）水平在不同疾病严重程度患者中表达水平。 方法 选取2014年2月～2016年12月我院诊治87例UC患者作为研究组，选取同期我院体检中心体检健康志愿者50名作为对照组，检测并比较各组间IL-6、IL-8、TNF-α水平。 结果 研究组IL-6、IL-8、TNF-α水平均高于对照组，两组比较差异有统计学意义（P<0.05）。根据Truelove-Witts标准，研究组87例患者分为轻度组33例，中度组34例，重度组20例。轻度组IL-6、IL-8、TNF-α水平均低于中度组、重度组，中度组IL-6、IL-8、TNF-α水平均低于重度组，各组间比较有统计学意义（P<0.05）。 结论 溃疡性结肠炎患者白介素水平显著升高，且随着疾病越严重白介素水平越高，白介素水平可作为辅助诊断及反映溃疡性结肠炎疾病严重程度有效指标。

[关键词] 溃疡性结肠炎；白介素；严重程度；白介素-6；白介素-8

[中图分类号] R574.6 [文献标识码] A [文章编号] 2095-0616（2017）07-190-03

Differential expression analysis of interleukin in patients with different severity of ulcerative colitis（UC）

LIU Jiefeng WU Bingzhuo HUANG Lichang ZHONG Chunmei CHEN Yanqing

LI Shihai

Medicine Department，Tangxia Hospital of Dongguan City，Dongguan 523710， China

[Abstract] Objective To discuss the expression level of interleukin-6（IL-6）、interleukin-8（IL-8） and tumor necrosis factor（TNF-α） in patients with different severity of ulcerative colitis. Methods 87 cases with UC in our hospital from Feb 2014 to Dec 2016 were selected as the study group，and 50 cases with healthy volunteers in our hospital during the same period were selected as control group.The levels of IL-6，IL-8 and TNF-α were detected and compared. Results The levels of IL-6，IL-8 and TNF-α of the study group were significantly higher than those of the control group， which showed significant difference（P<0.05）.According to Truelove-Witts criteria，87 cases in the study group were divided into mild group（33 cases），moderate group（34 cases） and severe group（20 cases）.The levels of IL-6，IL-8 and TNF-α in mild group were lower than those in moderate group and severe group.The levels of IL-6，IL-8 and TNF-α in moderate group were lower than those in severe group，which showed significant difference （P<0.05）. Conclusion Interleukin levels in patients with ulcerative colitis increase apparently，which increase with the severity of the disease.Interleukin levels can be used as an auxiliary diagnosis index and reflect the severity of ulcerative colitis disease.

[Key words] Ulcerative colitis；Interleukin；Severity；IL-6；IL-8

溃疡性结肠炎（UC）为遗传、环境及免疫功能相关性疾病，UC患者表现为肠道长期慢性炎症反应，在临床中具有较高发病率，临床中缺乏便捷、经济辅助诊断UC方法，造成疾病误诊、漏诊率升高，影响患者健康及生活质量[1-2]。白介素为临床中反映炎症反应重要临床指标，全身感染性或非感染性炎癥反应，均能刺激机体白介素水平升高，临床中

IL-6、IL-8及TNF-α水平检测反应灵敏度和特异性较高。本研究旨在探讨IL-6、IL-8、TNF-α水平在不同疾病严重程度UC患者中表达水平特征，现报道如下。

1 资料与方法

1.1 一般资料

选取2014年2月～2016年12月我院诊治87例UC患者作为研究组，选取同期我院体检中心体检健康自愿者50名作为对照组。研究组中患者诊断符合《我国对炎症性肠炎诊断治疗规范及共识意见》[3]，明确诊断为UC；对照组均为我院体检中心体检健康自愿者；两组研究者均在医师告知下了解本次研究，并自愿配合完成本次研究；排除有癌变倾向溃疡性结肠炎、放射性肠炎患者；……