王晶茹++陈德哲++刘佳

DOI：10.16662/j.cnki.1674-0742.2017.09.175

[摘要] 目的 探究分析TCD下脑血流动力学改变与轻度认知障碍患者的关系。 方法 随机选取聊城市人民医院收治的轻度认知障碍患者90例（2015年3月—2016年3月期间）作为研究组，另抽选同期健康体检人员90名作对照组，两组观察对象均接受TCD检查，对其脑血流动力学改变情况进行对比分析。 结果 研究组患者与对照组观察对象的大脑前动脉与中动脉的峰值流速分别为（60.35±12.72）cm/s与（63.97±16.83）cm/s，均值流速分别为（39.71±6.12）cm/s与（42.15±5.43）cm/s，比较差异有统计学意义（P<0.05）；其大脑后动脉为（57.03±14.16）cm/s，椎动脉为为（51.8±12.64）cm/s，基底动脉血流速度为（53.93±11.35）cm/s，与对照组对比差异无统计学意义（P>0.05）。 结论 轻度认知障碍患者普遍存在脑血流动力学异常情况，使用TCD检验对疾病的诊断具有较高的应用价值，值得在今后临床中广泛推广。

[关键词] TCD；脑血流动力学；轻度认知障碍

[中图分类号] R749.16 [文献标识码] A [文章编号] 1674-0742（2017）03（c）-0175-03

Correlation between the Cerebral Hemodynamics Change under TCD and Mild Cognitive Disorder

WANG Jing-ru， CHEN De-zhe， LIU Jia

Department of Neurology， Liaocheng Brain Hospital， Liaocheng，Shandong Province， 252000 China

[Abstract] Objective To study and analyze the correlation between the cerebral hemodynamics change under TCD and mild cognitive disorder. Methods 90 cases of patients with mild cognitive disorder admitted and treated in our hospital from March 2015 to March 2016 were selected as the research group， while 90 cases of healthy physical examination people were selected as the control group， and both groups received the TCD examination， and the changes of cerebral hemodynamics were compared. Results The anterior cerebral artery and median artery peak systolic velocities and mean velocities in the research group and the control group were respectively （60.35±12.72）cm/s，（63.97±16.83）cm/s and （39.71±6.12）cm/s，（42.15±5.43）cm/s，and the differences were statistically significant by comparison（P>0.05）， and the blood flow rate of arteria cerebri aborales， vertebral artery and basilar artery was respectively （57.03±14.16）cm/s，（51.8±12.64）cm/s and （53.93±11.35）cm/s， and the differences were not statistically significant by comparison（P>0.05）. Conclusion The abnormal situation of cerebral hemodynamics occurs to patients with mild cognitive disorder in common， and the application of TCD test is of higher application value to the diagnosis of diseases， which is worth wide promotion in clinic.

[Key words] TCD； Cerebral hemodynamics； Mild cognitive disorder

轻度认知功能障碍是具有异质性，多种疾病在一定阶段表现的一种疾病。该疾病主要指患者的认知功能或记忆功能存在轻度的障碍，但是对其日常的生活能力未产生明显影响[1]。轻度认知功能障碍是一种早期老年痴呆与正常老化之间的一种状态。该状态可伴随时间的推移，转化为血管性痴呆、阿尔茨海默病痴呆或其他类型痴呆。该院为探究TCD下脑血流动力学的改变对轻度认知障碍患者诊断的效果，特随机抽选2015年3月—2016年3月期间收治的90例轻度认知障碍患者与90名健康体检人群进行比较，现报道如下。

1 资料与方法

1.1 一般资料