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肝硬化患者血清生化指标的表达及临床意义

2017-04-07温小云方先松徐惠荣

中国当代医药 2017年6期
关键词:诊断

温小云++方先松++徐惠荣

[摘要]目的 探讨肝硬化疾病诊断中应用血清生化检验项目的可行性。方法 选取我院2013年1月~2016年6收治的50例被证实为肝硬化的患者和50例健康体检者为研究对象,将其分别设置为观察组、对照组。所有受检者均接受生化检验,比较两组受检者的血清胆汁酸(TBA)、胆碱酯酶(CHE)、天门冬氨酸氨基转换酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBil)、前白蛋白(PAB)、谷氨酸脱氢酶(GLDH)、亮氨酸氨基肽酶(LAP)、α-岩藻糖苷酶(AFU)、腺苷脱氨酸(ADA)等生化检验指标。结果 观察组的AST、ALP、TBA、TBil、GLDH、LAP、AFU、ADA等指标较对照组均明显更高(P<0.01),而观察组的PAB、CHE较对照组均明显更低(P<0.01)。结论 在肝硬化的临床诊断中,对患者进行生化检验,可通过其生化检验指标与健康人之间的差异,对肝硬化作出诊断。

[关键词]肝硬化;诊断;生化检验

[中图分类号] R657.3+1 [文献标识码] A [文章编号] 1674-4721(2017)02(c)-0129-03

The expression and clinical significance of serum biochemical indexes in patients with liver cirrhosis

WEN Xiao-Yun1 FANG Xian-song2 XU Hui-rong1

1.Department of Clinical Laboratory,the First Affiliated Hospital of Gannan School of Medicine in Jiangxi Province,Ganzhou 341000,China;2.Department of Blood Transfusion,the First Affiliated Hospital of Gannan School of Medicine in Jiangxi Province,Ganzhou 341000,China

[Abstract]Objective To study the application feasibility of serum biochemical tests of liver cirrhosis and the diagnosis of disease.Methods From January 2013 to June 2016,50 cases confirmed liver cirrhosis and 50 healthy subjects in the hospital were selected as the research object,they were set as the observation group and the control group.All subjects underwent biochemical tests,serum bile acid (TBA),cholinesterase (CHE),aspartate aminotransferase (AST),alkaline phosphatase (ALP),total bilirubin (TBil),prealbumin (PAB),glutamate dehydrogenase (GLDH).Leucine aminopeptidase (LAP),alpha fucosidase (AFU),adenosine deaminase (ADA) and acid biochemical index were compared between two groups.Results AST,ALP,TBA,TBil,GLDH,LAP,AFU,ADA index in the observation group were significantly higher than that in the control group (P<0.01),and PAB,CHE in the observation group were significantly lower than that in the control group (P<0.01).Conclusion In the clinical diagnosis of liver cirrhosis,patients are grven biochemical test,and the difference between the biochemical index and the health of people can make a diagnosis of the liver.

[Key words]Liver cirrhosis;Diagnosis;Biochemical test肝硬化是一種慢性进行性的肝脏纤维化病变,病情迁延不愈,往往伴随肝功能受损,且随着病情的发展,患者的肝功能损伤逐渐加重,甚至有可能发生癌变,危及患者的生命安全[1-3],因此,对肝硬化患者进行尽早诊断和积极治疗,具有十分重要的意义。血清生化检验属于临床检验医学中较为常见的一种,主要是通过对受检者的血液进行离心处理,得到血清后,检测血清中的各项指标,并将其检测结果与正常参考值进行比较,从而对受检者机体内是否存在病变以及病变程度进行判断,为临床诊断提供重要依据,在临床疾病的诊断与治疗中的应用十分广泛,在肝硬化的临床诊断中也有所应用[4],而关于血清生化检验对肝硬化的诊断价值如何则还有待证实。为证实血清生化检验对肝硬化的诊断价值,本研究选取50例肝硬化患者和50例健康体检者进行生化检验,并比较生化检验结果中的各项指标,现报道如下。……

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